ArticlePloS one2013
Natural killer cells from patients with chronic rhinosinusitis have impaired effector functions.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- Unveiling and validating biomarkers related to the IL-10 family in chronic sinusitis with nasal polyps: insights from transcriptomics and single-cell RNA sequencing analysis.Frontiers in molecular biosciences · 2024Article
- Immunological Aspects of Chronic Rhinosinusitis.Diagnostics (Basel, Switzerland) · 2022Review
- Chronic Rhinosinusitis,Biomedicines · 2022Review
- Ginsenoside F1 Attenuates Eosinophilic Inflammation in Chronic Rhinosinusitis by Promoting NK Cell Function.Journal of ginseng research · 2021Article
- Airway Natural Killer Cells and Bacteria in Health and Disease.Frontiers in immunology · 2020Review
- Role of Natural Killer Cells in Airway Inflammation.Allergy, asthma & immunology research · 2018Review
- Sinonasal T-cell expression of cytotoxic mediators granzyme B and perforin is reduced in patients with chronic rhinosinusitis.American journal of rhinology & allergy · 2017Article
- Bacterial Pathogens and the Microbiome.Otolaryngologic clinics of North America · 2017Review
- Natural killer cells regulate eosinophilic inflammation in chronic rhinosinusitis.Scientific reports · 2016Article
- Effects of thermal water inhalation in chronic upper respiratory tract infections in elderly and young patients.Immunity & ageing : I & A · 2016Article
- Clinical and biological markers of difficult-to-treat severe chronic rhinosinusitis.Current allergy and asthma reports · 2015Review
- Epidemiology of chronic rhinosinusitis, selected risk factors, comorbidities, and economic burden.GMS current topics in otorhinolaryngology, head and neck surgery · 2015Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer (NK) cells are multicompetent lymphocytes of the innate immune system that play a central role in host defense and immune regulation. Although increasing evidence suggests that innate immunity plays a key role in the pathogenesis of chronic rhinosinusitis (CRS), the role of NK cells in CRS has been poorly studied. This study aimed to characterize the peripheral blood NK cells from patients with CRS, and to compare the functions of these cells with those from non-CRS controls. The correlation between NK cell functional activity and prognosis was also assessed. Eighteen CRS patients and 19 healthy non-CRS controls were included. The patients with CRS were classified into two subgroups, namely a treatment-responsive group and recalcitrant group. NK cell degranulation was determined by measuring the cell surface expression of CD107a against 721.221 and K562 cells. Intracytoplasmic cytokine production was determined by flow cytometry. Compared to the controls, the NK cells of CRS group had an impaired ability to degranulate and to produce cytokines such as IFN-γ and TNF-α. The recalcitrant subgroup showed the most severe defects in NK cell effector functions. Moreover, the decreased NK cell functions in patients with CRS were associated with poor prognostic factors such as concomitant asthma and peripheral blood eosinophilia. NK cells, which were originally named for their ability to mediate spontaneous cytotoxicity towards diseased cells including infected cells, may play an important role in regulating the inflammatory process in CRS pathogenesis.
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