SynthesisPloS one2013
Measles contributes to rheumatoid arthritis: evidence from pathway and network analyses of genome-wide association studies.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- GLRB variants regulate nearby gene expression in human brain tissues.Scientific reports · 2017Pooled it
- A pathway analysis of genome-wide association study highlights novel type 2 diabetes risk pathways.Scientific reports · 2017Pooled it
- Pooled it
- Integrative Analysis of Transcriptome-Wide Association Study and Gene-Based Association Analysis Identifies In Silico Candidate Genes Associated with Juvenile Idiopathic Arthritis.International journal of molecular sciences · 2022Article
- ATRPred: A machine learning based tool for clinical decision making of anti-TNF treatment in rheumatoid arthritis patients.PLoS computational biology · 2022Article
- The Protective Effect of the Soluble Egg Antigen ofFrontiers in immunology · 2022Article
- rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues.BMC medicine · 2021Article
- Comparative Transcriptomic Analysis Reveals the Immunosuppressive Targets of Mesalazine in Dextran Sulfate Sodium-Induced Ulcerative Colitis.Frontiers in genetics · 2021Article
- Identification of Key Candidate Genes Related to Inflammatory Osteolysis Associated with Vitamin E-Blended UHMWPE Debris of Orthopedic Implants by Integrated Bioinformatics Analysis and Experimental Confirmation.Journal of inflammation research · 2021Article
- Analyzing Genome-Wide Association Study Dataset Highlights Immune Pathways in Lip Bone Mineral Density.Frontiers in genetics · 2020Article
- Genetic and Expression Analysis of COPI Genes and Alzheimer's Disease Susceptibility.Frontiers in genetics · 2019Article
- Integrating Genome-Wide Association Studies With Pathway Analysis and Gene Expression Analysis Highlights Novel Osteoarthritis Risk Pathways and Genes.Frontiers in genetics · 2019Article
- Identification of potential biomarkers for differential diagnosis between rheumatoid arthritis and osteoarthritis via integrative genome‑wide gene expression profiling analysis.Molecular medicine reports · 2019Article
- Alzheimer's Disease and Rheumatoid Arthritis: A Mendelian Randomization Study.Frontiers in neuroscience · 2018Article
- Inverse relationship between serum vitamin D level and measles antibody titer: A cross-sectional analysis of NHANES, 2001-2004.PloS one · 2018Article
- A time-course microarray data analysis reveals consistent dysregulated genes and upstream microRNAs in autoantibody-mediated arthritis.Journal of orthopaedic surgery and research · 2017Article
- Genome-wide network-based pathway analysis of CSF t-tau/Aβ1-42 ratio in the ADNI cohort.BMC genomics · 2017Article
- Update on the genetic architecture of rheumatoid arthritis.Nature reviews. Rheumatology · 2017Review
- Multiple analyses of large-scale genome-wide association study highlight new risk pathways in lumbar spine bone mineral density.Oncotarget · 2016Article
- Integrative analysis of genome-wide association studies and gene expression analysis identifies pathways associated with rheumatoid arthritis.Oncotarget · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growing evidence from epidemiological studies indicates the association between rheumatoid arthritis (RA) and measles. However, the exact mechanism for this association is still unclear now. We consider that the strong association between both diseases may be caused by shared genetic pathways. We performed a pathway analysis of large-scale RA genome-wide association studies (GWAS) dataset with 5,539 cases and 20,169 controls of European descent. Meanwhile, we evaluated our findings using previously identified RA loci, protein-protein interaction network and previous results from pathway analysis of RA and other autoimmune diseases GWAS. We confirmed four pathways including Cytokine-cytokine receptor interaction, Jak-STAT signaling, T cell receptor signaling and Cell adhesion molecules. Meanwhile, we highlighted for the first time the involvement of Measles and Intestinal immune network for IgA production pathways in RA. Our results may explain the strong association between RA and measles, which may be caused by the shared genetic pathway. We believe that our results will be helpful for future genetic studies in RA pathogenesis and may significantly assist in the development of therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.