ArticlePloS one2013
Characterization of the Th profile of the bovine endometrium during the oestrous cycle and early pregnancy.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 88 citations in OpenAlex.
- Inflammation in the endometrium of the tammar wallaby (Macropus eugenii) at the time of birth.Reproduction & fertility · 2026Article
- Regulation of the maternal immune system during early bovine pregnancy.Reproduction & fertility · 2026Review
- Regulatory T cells in human pregnancy: mechanisms, dysregulation, and therapeutic perspectives.Frontiers in immunology · 2026Review
- Progesterone-mediated immunomodulation in ruminant early pregnancy: mechanisms and implications for bovine fertility.Veterinary research communications · 2025Review
- Postpartum Uterine Involution in Cows: Quantitative Assessment of Structural Remodeling and Immune Cell Infiltration.Animals : an open access journal from MDPI · 2025Article
- The interleukin-6 signal transducer receptor subunit is required for optimal in vitro bovine embryo development†.Biology of reproduction · 2025Article
- Human Recombinant Interleukin-6 and Leukemia Inhibitory Factor Improve Inner Cell Mass Cell Number but Lack Cryoprotective Activities on In Vitro-Produced Bovine Blastocysts.Animals : an open access journal from MDPI · 2025Article
- Changes in vaginal cytokines concentrations during artificial insemination and natural service in beef heifers.BMC research notes · 2024Article
- Molecular approaches to mammalian uterine receptivity for conceptus implantation.The Journal of reproduction and development · 2024Review
- Role of chemokines in regulating luteal and uterine functions in pregnant cows.The Journal of reproduction and development · 2024Review
- Effects of parity and early pregnancy on peripheral blood leukocytes in dairy cattle.bioRxiv : the preprint server for biology · 2024Article
- Extensive rewiring of the gene regulatory interactions between in vitro-produced conceptuses and endometrium during attachment.PNAS nexus · 2023Article
- Immune responses in the uterine mucosa: clues for vaccine development in pigs.Frontiers in immunology · 2023Review
- Article
- Cytokines That Serve as Embryokines in Cattle.Animals : an open access journal from MDPI · 2021Review
- The effects of protein level on cytokines and chemokines in the uterine environment of beef heifers during development.Journal of animal science · 2021Article
- Editorial: Veterinary Reproductive Immunology.Frontiers in veterinary science · 2021Article
- Possible impact of neutrophils on immune responses during early pregnancy in ruminants.Animal reproduction · 2021Review
- Actions of putative embryokines on development of the preimplantation bovine embryo to the blastocyst stage.Journal of dairy science · 2020Article
- Transcriptome, Spliceosome and Editome Expression Patterns of the Porcine Endometrium in Response to a Single Subclinical Dose ofInternational journal of molecular sciences · 2020Article
Corrections and comments
- Erratum issued
- Erratum issuedMansourri-Attia, Nadéra [corrected to Mansouri-Attia, Nadéra]
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite extensive research in the area of cow fertility, the extent to which the maternal immune system is modulated during pregnancy in cattle remains unclear. Therefore, the objective of the current study was to characterize the presence and response profile of B, T-helper (LTh), T- cytotoxic (LTc), gamma delta-T (γδT) and natural killer (NK) lymphocytes in terms of cell number, distribution and cytokine expression in bovine endometrial tissue to pregnancy. Endometrial tissue samples were collected from beef heifers on Days 5, 7, 13 and 16 of the estrous cycle or pregnancy. Samples were analysed by immunofluorescence to identify the presence and abundance of B-B7 (B-cells), CD4 (LTh), CD8 (LTc), γδT cell receptor (TCR) and CD335/NKp46 (NK cells) -positive immune cells. Quantitative real time PCR (QPCR) was carried out to analyse mRNA relative abundance of FOXP3 (a marker of regulatory T (Treg) cells) and a panel of immune factors, including MHC-I, LIF, Interleukins 1, 2, 6, 8, 10, 11,12A, IFNa and IFNG. Results indicate that B-B7+ cells are quite populous in bovine endometrial tissue, CD4+ and CD8+ -cells are present in moderate numbers and γδTCR+ and CD335+ cells are present in low numbers. Pregnancy affected the total number and distribution pattern of the NK cell population, with the most significant variation observed on Day 16 of pregnancy. Neither B lymphocytes nor T lymphocyte subsets were regulated temporally during the oestrous cycle or by pregnancy prior to implantation. mRNA transcript abundance of the immune factors LIF, IL1b, IL8 and IL12A, IFNa and IFNG, expression was regulated temporally during the estrous cycle and LIF, IL1b, IL-10, IL11, IL12A were also temporally regulated during pregnancy. In conclusion, the endometrial immune profile of the oestrous cycle favours a Th2 environment in anticipation of pregnancy and the presence of an embryo acts to fine tune this environment.
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