ArticleBeilstein journal of organic chemistry2013
Synthesis of enantiomerically pure N-(2,3-dihydroxypropyl)arylamides via oxidative esterification.
Article in Beilstein journal of organic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Radical [1,3] Rearrangements of Breslow Intermediates.Angewandte Chemie (International ed. in English) · 2016Article
- Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies.EXCLI journal · 2016Article
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7 authors.
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Abstract
A highly efficient synthesis of enantiomerically pure (S) and (R)-isomers of N-(2,3-dihydroxypropyl)arylamides has been developed with good overall yields in a two step process. The key step involves the ring opening of the chiral epoxide with a nitrogen heterocyclic carbene (NHC) and further rearrangement to chiral N-(2,3-dihydroxypropyl)arylamides in high yields and enantioselectivity. During the reaction, no erosion in chiral purity was observed.
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