ArticleBeilstein journal of organic chemistry2013
One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor.
Article in Beilstein journal of organic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 40 citations in OpenAlex.
- Microwave-Assisted Organic Synthesis: An Eco-Friendly Method of Green Chemistry.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Impact of Microwaves on Organic Synthesis and Strategies toward Flow Processes and Scaling Up.The Journal of organic chemistry · 2021Article
- Synthesis of α-amino-1,3-dicarbonyl compounds via Ugi flow chemistry reaction: access to functionalized 1,2,3-triazoles.Molecular diversity · 2017Article
- Transition metal-free one-pot synthesis of nitrogen-containing heterocycles.Molecular diversity · 2016Review
- Groebke-Blackburn-Bienaymé multicomponent reaction: emerging chemistry for drug discovery.Molecular diversity · 2016Review
- Synthesis and Biological Evaluation of New Tricyclic Dihydropyridine Based Derivatives on Potassium Channels.Iranian journal of pharmaceutical research : IJPR · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
The Bohlmann-Rahtz pyridine synthesis and the Hantzsch dihydropyridine synthesis can be carried out in a microwave flow reactor or using a conductive heating flow platform for the continuous processing of material. In the Bohlmann-Rahtz reaction, the use of a Brønsted acid catalyst allows Michael addition and cyclodehydration to be carried out in a single step without isolation of intermediates to give the corresponding trisubstituted pyridine as a single regioisomer in good yield. Furthermore, 3-substituted propargyl aldehydes undergo Hantzsch dihydropyridine synthesis in preference to Bohlmann-Rahtz reaction in a very high yielding process that is readily transferred to continuous flow processing.
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