ReviewFrontiers in microbiology2013
Life at high salt concentrations, intracellular KCl concentrations, and acidic proteomes.
Review in Frontiers in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
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125 citing papers in PubMed, 239 citations in OpenAlex.
- Carotenoids of Halophilic Archaea: Production, Properties and Biotechnological Applications.Probiotics and antimicrobial proteins · 2026Review
- Fluorescent probes as markers of cell envelope structure and function in halophilic archaea.Scientific reports · 2026Article
- Metabolic adaptations of extremophiles and their applications in environmental biotechnology.World journal of microbiology & biotechnology · 2026Review
- Uncovering transcriptional processes in microbial communities adapted to differing saline conditions in salt-weathered historic buildings.Microbiome · 2026Article
- Gut Microbiota as a Mediator of Dietary Salt Effects on Blood Pressure.International journal of molecular sciences · 2026Review
- quickARSC: standalone package and web interface for profiling elemental stoichiometry of proteomes.Microbiology resource announcements · 2026Article
- New lineages provide insights into the convergent evolution of extreme salt adaptation within symbiotic Archaea.Molecular biology and evolution · 2026Article
- Pulsed Electric Fields for Emerging Single-Cell Bioprocessing in Food Applications: Electropermeabilization Mechanisms and Design Principles.Comprehensive reviews in food science and food safety · 2026Review
- Improved uranium bioleaching in brackish environments via microbial consortium using RSM based modelling and optimization.Scientific reports · 2026Article
- Coordinated proteome-scale remodeling underlies polyextremophilic survival in Antarctic cryo-hypersaline brines.Frontiers in microbiology · 2026Article
- Expanding genomic resources for heritage science: characterization of selected microbial isolates from salt-weathered historic sites.Frontiers in microbiology · 2026Article
- Investigation of salt-bridge interactions underlying salt activation of halophilic methionine sulfoxide reductase A.Frontiers in microbiology · 2026Article
- Saline-alkaline mediated chemotaxis in the plant growth-promoting rhizobacterium Enterobacter cloacae.FEMS microbiology ecology · 2025Article
- Bacterioruberin (CNutrients · 2025Review
- Cell-supporting cytoskeletons and phagocytic acquisition of compatible solutes emerge as common strategies for high-salt adaptation in different ciliates.Science China. Life sciences · 2025Article
- Biogeography and host interactions of CPR and DPANN viruses in acid mine drainage sediments.Nature communications · 2025Article
- Extremophile-Derived Bioactives in Cosmeceuticals: Bridging Nutraceuticals and Skincare for Holistic Wellness.Life (Basel, Switzerland) · 2025Review
- Article
- Natranaerobius thermophilus: an anaerobic, polyextremophilic microorganism with unique properties and adaptive mechanisms.Extremophiles : life under extreme conditions · 2025Review
- Domain-specific osmoadaptation revealed by metatranscriptomic analysis in hypersaline environments.Scientific reports · 2025Article
65 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extremely halophilic microorganisms that accumulate KCl for osmotic balance (the Halobacteriaceae, Salinibacter) have a large excess of acidic amino acids in their proteins. This minireview explores the occurrence of acidic proteomes in halophiles of different physiology and phylogenetic affiliation. For fermentative bacteria of the order Halanaerobiales, known to accumulate KCl, an acidic proteome was predicted. However, this is not confirmed by genome analysis. The reported excess of acidic amino acids is due to a high content of Gln and Asn, which yield Glu and Asp upon acid hydrolysis. The closely related Halorhodospira halophila and Halorhodospira halochloris use different strategies to cope with high salt. The first has an acidic proteome and accumulates high KCl concentrations at high salt concentrations; the second does not accumulate KCl and lacks an acidic proteome. Acidic proteomes can be predicted from the genomes of some moderately halophilic aerobes that accumulate organic osmotic solutes (Halomonas elongata, Chromohalobacter salexigens) and some marine bacteria. Based on the information on cultured species it is possible to understand the pI profiles predicted from metagenomic data from hypersaline environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.