ArticleFrontiers in computational neuroscience2013
A possible role of astrocytes in contextual memory retrieval: An analysis obtained using a quantitative framework.
Article in Frontiers in computational neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Cholinergic signaling to CA1 astrocytes controls fear extinction.Science advances · 2025Article
- The computational power of the human brain.Frontiers in cellular neuroscience · 2023Review
- Controlling synchronization of gamma oscillations by astrocytic modulation in a model hippocampal neural network.Scientific reports · 2022Article
- Modeling Working Memory in a Spiking Neuron Network Accompanied by Astrocytes.Frontiers in cellular neuroscience · 2021Article
- Unraveling Aβ-Mediated Multi-Pathway Calcium Dynamics in Astrocytes: Implications for Alzheimer's Disease Treatment From Simulations.Frontiers in physiology · 2021Article
- Effects of Several Classes of Voltage-Gated Ion Channel Conductances on Gamma and Theta Oscillations in a Hippocampal Microcircuit Model.Frontiers in computational neuroscience · 2021Article
- Spatiotemporal model of tripartite synapse with perinodal astrocytic process.Journal of computational neuroscience · 2020Article
- The Human Body as a Super Network: Digital Methods to Analyze the Propagation of Aging.Frontiers in aging neuroscience · 2020Article
- Astrocyte function from information processing to cognition and cognitive impairment.Nature neuroscience · 2019Review
- Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity.Frontiers in physiology · 2019Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Article
- Reproducibility and Comparability of Computational Models for Astrocyte Calcium Excitability.Frontiers in neuroinformatics · 2017Article
- Mathematical Modeling in Neuroscience: Neuronal Activity and Its Modulation by Astrocytes.Frontiers in integrative neuroscience · 2016Article
- Astrocytes Modulate Local Field Potential Rhythm.Frontiers in integrative neuroscience · 2015Article
- Interactions of HIV and drugs of abuse: the importance of glia, neural progenitors, and host genetic factors.International review of neurobiology · 2014Review
- Data and model tango to aid the understanding of astrocyte-neuron signaling.Frontiers in computational neuroscience · 2014Article
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2 authors.
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Abstract
The hippocampus is central to our understanding of memory formation and retrieval. Its CA1 region is known for encoding contextual memory. Here, using a computational approach, which embeds existing physiological data, we propose a particular role of astrocytes in contextual memory retrieval. We provide a quantitative framework under which the astrocyte modulates the firing of a context-associated CA1 pyramidal neurons, resulting in a prominent tuning of neurons to a delta rhythm. Using the very framework, we further studied astrocytic function in the modulation of neuronal firing under pathological conditions, i.e., during astrocytic induction of epileptiform discharge in CA1 pyramidal neurons. Thus, we provide a quantitative framework that would aid understanding of the Schaffer collateral-CA1 tripartite synapse in health and disease.
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