ArticlePLoS pathogens2013
IL-4Rα-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection.
Article in PLoS pathogens, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Deletion of IL-4Rα signaling on B cells limits hyperresponsiveness depending on antigen load.The Journal of allergy and clinical immunology · 2021Article
- Context-dependent roles of B cells during intestinal helminth infection.PLoS neglected tropical diseases · 2021Review
- Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection.Cell host & microbe · 2021Article
- IL-4-Responsive B Cells Are Detrimental During Chronic Tuberculosis Infection in Mice.Frontiers in immunology · 2021Article
- Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies.Clinical microbiology reviews · 2020Review
- Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring.Science advances · 2019Article
- Helminth-induced IL-4 expands bystander memory CD8Nature communications · 2018Article
- Hematopoietic cell-derived RELMα regulates hookworm immunity through effects on macrophages.Journal of leukocyte biology · 2018Article
- Immunity to gastrointestinal nematode infections.Mucosal immunology · 2018Review
- IgG1 Is Required for Optimal Protection after Immunization with the Purified Porin OmpD fromJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Antigen presentation by B cells guides programing of memory CD4European journal of immunology · 2016Article
- Immune polarization by hookworms: taking cues from T helper type 2, type 2 innate lymphoid cells and alternatively activated macrophages.Immunology · 2016Review
- Surfactant Protein-D Is Essential for Immunity to Helminth Infection.PLoS pathogens · 2016Article
- Antibody-mediated trapping of helminth larvae requires CD11b and Fcγ receptor I.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Eosinophils mediate protective immunity against secondary nematode infection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Natural and vaccine-mediated immunity to Salmonella Typhimurium is impaired by the helminth Nippostrongylus brasiliensis.PLoS neglected tropical diseases · 2014Article
- Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4⁺ T cell responses.PLoS pathogens · 2014Article
- B1b cells recognize protective antigens after natural infection and vaccination.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
In this study, B cell function in protective T(H)2 immunity against N. brasiliensis infection was investigated. Protection against secondary infection depended on IL-4Rα and IL-13; but not IL-4. Protection did not associate with parasite specific antibody responses. Re-infection of B cell-specific IL-4Rα⁻/⁻ mice resulted in increased worm burdens compared to control mice, despite their equivalent capacity to control primary infection. Impaired protection correlated with reduced lymphocyte IL-13 production and B cell MHC class II and CD86 surface expression. Adoptive transfer of in vivo N. brasiliensis primed IL-4Rα expressing B cells into naïve BALB/c mice, but not IL-4Rα or IL-13 deficient B cells, conferred protection against primary N. brasiliensis infection. This protection required MHC class II compatibility on B cells suggesting cognate interactions by B cells with CD4⁺ T cells were important to co-ordinate immunity. Furthermore, the rapid nature of these protective effects by B cells suggested non-BCR mediated mechanisms, such as via Toll Like Receptors, was involved, and this was supported by transfer experiments using antigen pulsed Myd88⁻/⁻ B cells. These data suggest TLR dependent antigen processing by IL-4Rα-responsive B cells producing IL-13 contribute significantly to CD4⁺ T cell-mediated protective immunity against N. brasiliensis infection.
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