ArticlePLoS pathogens2013
Transcriptional regulation of Culex pipiens mosquitoes by Wolbachia influences cytoplasmic incompatibility.
Article in PLoS pathogens, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Genomic islands in Wolbachia prophages drive amplification and diversification of cytoplasmic incompatibility genes in Culex pipiens.Genetics · 2026Article
- Extensive mobilome dynamics in a widespread endosymbiont: long read metagenomics reveal dimeric plasmids and highly fragmented prophages in Wolbachia from Culex pipiens.Research square · 2026Article
- Article
- Pangenomic analysis ofFrontiers in microbiology · 2023Article
- Review
- Evolution-guided mutagenesis of the cytoplasmic incompatibility proteins: Identifying CifA's complex functional repertoire and new essential regions in CifB.PLoS pathogens · 2020Article
- Wolbachia transinfections in Culex quinquefasciatus generate cytoplasmic incompatibility.Insect molecular biology · 2020Article
- Trends in Symbiont-Induced Host Cellular Differentiation.Results and problems in cell differentiation · 2020Article
- The phage gene wmk is a candidate for male killing by a bacterial endosymbiont.PLoS pathogens · 2019Article
- Loss of cytoplasmic incompatibility and minimal fecundity effects explain relatively low Wolbachia frequencies in Drosophila mauritiana.Evolution; international journal of organic evolution · 2019Article
- Mi Casa es Su Casa: how an intracellular symbiont manipulates host biology.Environmental microbiology · 2017Article
- Genomes of Candidatus Wolbachia bourtzisii wDacA and Candidatus Wolbachia pipientis wDacB from the Cochineal Insect Dactylopius coccus (Hemiptera: Dactylopiidae).G3 (Bethesda, Md.) · 2016Article
- Eukaryotic association module in phage WO genomes from Wolbachia.Nature communications · 2016Article
- Wolbachia Endobacteria in Natural Populations of Culex pipiens of Iran and Its Phylogenetic Congruence.Journal of arthropod-borne diseases · 2016Article
- Comparative Genomics of a Parthenogenesis-Inducing Wolbachia Symbiont.G3 (Bethesda, Md.) · 2016Article
- Bacteriophage WO Can Mediate Horizontal Gene Transfer in EndosymbioticFrontiers in microbiology · 2016Article
- Review
- Dynamics of Wolbachia pipientis Gene Expression Across the Drosophila melanogaster Life Cycle.G3 (Bethesda, Md.) · 2015Article
- Wolbachia Influences the Production of Octopamine and Affects Drosophila Male Aggression.Applied and environmental microbiology · 2015Article
- Extreme divergence of Wolbachia tropism for the stem-cell-niche in the Drosophila testis.PLoS pathogens · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Cytoplasmic incompatibility (CI) induced by the endosymbiont Wolbachia pipientis causes complex patterns of crossing sterility between populations of the Culex pipiens group of mosquitoes. The molecular basis of the phenotype is yet to be defined. In order to investigate what host changes may underlie CI at the molecular level, we examined the transcription of a homolog of the Drosophila melanogaster gene grauzone that encodes a zinc finger protein and acts as a regulator of female meiosis, in which mutations can cause sterility. Upregulation was observed in Wolbachia-infected C. pipiens group individuals relative to Wolbachia-cured lines and the level of upregulation differed between lines that were reproductively incompatible. Knockdown analysis of this gene using RNAi showed an effect on hatch rates in a Wolbachia infected Culex molestus line. Furthermore, in later stages of development an effect on developmental progression in CI embryos occurs in bidirectionally incompatible crosses. The genome of a wPip Wolbachia strain variant from Culex molestus was sequenced and compared with the genome of a wPip variant with which it was incompatible. Three genes in inserted or deleted regions were newly identified in the C. molestus wPip genome, one of which is a transcriptional regulator labelled wtrM. When this gene was transfected into adult Culex mosquitoes, upregulation of the grauzone homolog was observed. These data suggest that Wolbachia-mediated regulation of host gene expression is a component of the mechanism of cytoplasmic incompatibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.