ArticlePLoS computational biology2013
Synaptic scaling enables dynamically distinct short- and long-term memory formation.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Neuromodulatory Gating of Synaptic Plasticity: Mechanisms, Motivation, and Clinical Dysfunction Across Scales.Synapse (New York, N.Y.) · 2026Review
- Incremental self-organization of spatio-temporal spike pattern detection.Scientific reports · 2025Article
- Article
- Effects of within-day intervals on adaptation to visually induced motion sickness in a virtual-reality motorcycling simulator.Scientific reports · 2024Article
- Inhibitory neurons control the consolidation of neural assemblies via adaptation to selective stimuli.Scientific reports · 2023Article
- Memory destabilization during reconsolidation: a consequence of homeostatic plasticity?Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Homeostatic synaptic scaling establishes the specificity of an associative memory.Current biology : CB · 2021Article
- Memory consolidation and improvement by synaptic tagging and capture in recurrent neural networks.Communications biology · 2021Article
- Unsupervised Learning and Clustered Connectivity Enhance Reinforcement Learning in Spiking Neural Networks.Frontiers in computational neuroscience · 2021Article
- The Interplay of Synaptic Plasticity and Scaling Enables Self-Organized Formation and Allocation of Multiple Memory Representations.Frontiers in neural circuits · 2020Article
- Self-organized reactivation maintains and reinforces memories despite synaptic turnover.eLife · 2019Article
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- A Theoretical Framework to Derive Simple, Firing-Rate-Dependent Mathematical Models of Synaptic Plasticity.Frontiers in computational neuroscience · 2019Article
- Principles underlying the input-dependent formation and organization of memories.Network neuroscience (Cambridge, Mass.) · 2019Article
- Working Memory Requires a Combination of Transient and Attractor-Dominated Dynamics to Process Unreliably Timed Inputs.Scientific reports · 2017Article
- On the Computational Power of Spiking Neural P Systems with Self-Organization.Scientific reports · 2016Article
- Spike-Based Bayesian-Hebbian Learning of Temporal Sequences.PLoS computational biology · 2016Article
- The right time to learn: mechanisms and optimization of spaced learning.Nature reviews. Neuroscience · 2016Review
- Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression.PloS one · 2016Article
- A Unified Dynamic Model for Learning, Replay, and Sharp-Wave/Ripples.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory storage in the brain relies on mechanisms acting on time scales from minutes, for long-term synaptic potentiation, to days, for memory consolidation. During such processes, neural circuits distinguish synapses relevant for forming a long-term storage, which are consolidated, from synapses of short-term storage, which fade. How time scale integration and synaptic differentiation is simultaneously achieved remains unclear. Here we show that synaptic scaling - a slow process usually associated with the maintenance of activity homeostasis - combined with synaptic plasticity may simultaneously achieve both, thereby providing a natural separation of short- from long-term storage. The interaction between plasticity and scaling provides also an explanation for an established paradox where memory consolidation critically depends on the exact order of learning and recall. These results indicate that scaling may be fundamental for stabilizing memories, providing a dynamic link between early and late memory formation processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.