ArticlePLoS computational biology2013
Unraveling adaptation in eukaryotic pathways: lessons from protocells.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Identification and quantification of irreversibility in stochastic systems.Physical chemistry chemical physics : PCCP · 2026Review
- Drift and Behavior of E. coli Cells.Biophysical journal · 2017Article
- Information processing in bacteria: memory, computation, and statistical physics: a key issues review.Reports on progress in physics. Physical Society (Great Britain) · 2016Review
- The lag-phase during diauxic growth is a trade-off between fast adaptation and high growth rate.Scientific reports · 2016Article
- Free energy cost of reducing noise while maintaining a high sensitivity.Physical review letters · 2015Article
- Optimal resource allocation in cellular sensing systems.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Thermodynamic costs of information processing in sensory adaptation.PLoS computational biology · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic adaptation pathways operate within wide-ranging environmental conditions without stimulus saturation. Despite numerous differences in the adaptation mechanisms employed by bacteria and eukaryotes, all require energy consumption. Here, we present two minimal models showing that expenditure of energy by the cell is not essential for adaptation. Both models share important features with large eukaryotic cells: they employ small diffusible molecules and involve receptor subunits resembling highly conserved G-protein cascades. Analyzing the drawbacks of these models helps us understand the benefits of energy consumption, in terms of adjustability of response and adaptation times as well as separation of cell-external sensing and cell-internal signaling. Our work thus sheds new light on the evolution of adaptation mechanisms in complex systems.
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Registered trials
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