ArticlePLoS computational biology2013
Attention-dependent modulation of cortical taste circuits revealed by Granger causality with signal-dependent noise.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Using real-time fMRI to influence effective connectivity in the developing emotion regulation network.NeuroImage · 2016Trial
- Corticomuscular coupling study for post-stroke rehabilitation: a scoping review.Journal of neuroengineering and rehabilitation · 2025Article
- Emotion, Motivation, Reasoning, and How Their Brain Systems Are Related.Brain sciences · 2025Review
- Predicting attentional focus: Heartbeat-evoked responses and brain dynamics during interoceptive and exteroceptive processing.PNAS nexus · 2024Article
- Orbitofrontal cortex conveys stimulus and task information to the auditory cortex.Current biology : CB · 2023Article
- Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala.Brain structure & function · 2023Review
- Orbitofrontal cortex connectivity is associated with food reward and body weight in humans.Social cognitive and affective neuroscience · 2023Article
- The orbitofrontal cortex, food reward, body weight and obesity.Social cognitive and affective neuroscience · 2023Article
- Functional Connectivity of the Chemosenses: A Review.Frontiers in systems neuroscience · 2022Review
- Mind Causality: A Computational Neuroscience Approach.Frontiers in computational neuroscience · 2021Article
- The orbitofrontal cortex: reward, emotion and depression.Brain communications · 2020Review
- Effective connectivity of the right anterior insula in schizophrenia: The salience network and task-negative to task-positive transition.NeuroImage. Clinical · 2020Article
- Effective connectivity between Broca's area and amygdala as a mechanism of top-down control in worry.Clinical psychological science : a journal of the Association for Psychological Science · 2020Article
- Intensity-related distribution of sweet and bitter taste fMRI responses in the insular cortex.Human brain mapping · 2019Article
- Article
- Decentralized temporal independent component analysis: Leveraging fMRI data in collaborative settings.NeuroImage · 2019Article
- The Functional Architecture of the Brain Underlies Strategic Deception in Impression Management.Frontiers in human neuroscience · 2017Article
- Altered structural and effective connectivity in anorexia and bulimia nervosa in circuits that regulate energy and reward homeostasis.Translational psychiatry · 2016Article
- A Nonlinear Causality Estimator Based on Non-Parametric Multiplicative Regression.Frontiers in neuroinformatics · 2016Article
- Age differences in the brain mechanisms of good taste.NeuroImage · 2015Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We show, for the first time, that in cortical areas, for example the insular, orbitofrontal, and lateral prefrontal cortex, there is signal-dependent noise in the fMRI blood-oxygen level dependent (BOLD) time series, with the variance of the noise increasing approximately linearly with the square of the signal. Classical Granger causal models are based on autoregressive models with time invariant covariance structure, and thus do not take this signal-dependent noise into account. To address this limitation, here we describe a Granger causal model with signal-dependent noise, and a novel, likelihood ratio test for causal inferences. We apply this approach to the data from an fMRI study to investigate the source of the top-down attentional control of taste intensity and taste pleasantness processing. The Granger causality with signal-dependent noise analysis reveals effects not identified by classical Granger causal analysis. In particular, there is a top-down effect from the posterior lateral prefrontal cortex to the insular taste cortex during attention to intensity but not to pleasantness, and there is a top-down effect from the anterior and posterior lateral prefrontal cortex to the orbitofrontal cortex during attention to pleasantness but not to intensity. In addition, there is stronger forward effective connectivity from the insular taste cortex to the orbitofrontal cortex during attention to pleasantness than during attention to intensity. These findings indicate the importance of explicitly modeling signal-dependent noise in functional neuroimaging, and reveal some of the processes involved in a biased activation theory of selective attention.
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