ArticlePLoS biology2013
The impact of gene expression variation on the robustness and evolvability of a developmental gene regulatory network.
Article in PLoS biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 84 citations in OpenAlex.
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- From genome to anatomy: The architecture and evolution of the skeletogenic gene regulatory network of sea urchins and other echinoderms.Genesis (New York, N.Y. : 2000) · 2018Review
- Parallel evolution of gene expression between trophic specialists despite divergent genotypes and morphologies.Evolution letters · 2018Article
- Advancing behavioural genomics by considering timescale.Nature communications · 2018Review
- Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen.Nature communications · 2018Article
- Differential gene expression during early development in recently evolved and sympatric Arctic charr morphs.PeerJ · 2018Article
- Modularity Facilitates Flexible Tuning of Plastic and Evolutionary Gene Expression Responses during Early Divergence.Genome biology and evolution · 2018Article
- Environmental epigenetics in zebrafish.Epigenetics & chromatin · 2017Review
- Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity.eLife · 2017Article
- Gene expression profiling during the embryo-to-larva transition in the giant red sea urchinEcology and evolution · 2017Article
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6 authors at 2 institutions in 1 country.
Funding
Abstract
Regulatory interactions buffer development against genetic and environmental perturbations, but adaptation requires phenotypes to change. We investigated the relationship between robustness and evolvability within the gene regulatory network underlying development of the larval skeleton in the sea urchin Strongylocentrotus purpuratus. We find extensive variation in gene expression in this network throughout development in a natural population, some of which has a heritable genetic basis. Switch-like regulatory interactions predominate during early development, buffer expression variation, and may promote the accumulation of cryptic genetic variation affecting early stages. Regulatory interactions during later development are typically more sensitive (linear), allowing variation in expression to affect downstream target genes. Variation in skeletal morphology is associated primarily with expression variation of a few, primarily structural, genes at terminal positions within the network. These results indicate that the position and properties of gene interactions within a network can have important evolutionary consequences independent of their immediate regulatory role.
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