ArticleInternational journal of nanomedicine2013
Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study.
Article in International journal of nanomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Engineered biosynthesis of hyaluronic acid in Corynebacterium glutamicum and green synthesis of HA-silver nanocomposites for advanced antimicrobial wound dressings.Scientific reports · 2026Article
- Green Synthesis of Silver Nanoparticles and Polymeric Nanofiber Composites: Fabrications, Mechanisms, and Applications.Polymers · 2025Review
- Polyacrylonitrile/Silver Nanoparticles Composite for Catalytic Dye Reduction and Real-Time Monitoring.Polymers · 2025Article
- Review
- Arginine-Biofunctionalized Ternary Hydrogel Scaffolds of Carboxymethyl Cellulose-Chitosan-Polyvinyl Alcohol to Deliver Cell Therapy for Wound Healing.Gels (Basel, Switzerland) · 2024Article
- Therapeutic effects of electrospun chitosan nanofibers on animal skin wounds: A systematic review and meta-analysis.International journal of pharmaceutics: X · 2023Review
- SARS-CoV-2 Papain-like Protease Responsive ZnO/Daclatasvir-Loaded Chitosan/Gelatin Nanofibers as Smart Antimicrobial Medical Textiles: In Silico, In Vitro and Cell Studies.Pharmaceutics · 2023Article
- Design, development, in-vitro and in-vivo evaluation of polylactic acid-based multifunctional nanofibrous patches for efficient healing of diabetic wounds.Scientific reports · 2023Article
- Bioengineered Water-Responsive Carboxymethyl Cellulose/Poly(vinyl alcohol) Hydrogel Hybrids for Wound Dressing and Skin Tissue Engineering Applications.Gels (Basel, Switzerland) · 2023Article
- Novel fabrication of bi-metal oxide hybrid nanocomposites for synergetic enhancement of in vivo healing and wound care after caesarean section surgery.International wound journal · 2022Article
- Metal-Based Nanoparticles: Antibacterial Mechanisms and Biomedical Application.Microorganisms · 2022Review
- Cyanine-Doped Nanofiber Mats for Laser Tissue Bonding.Nanomaterials (Basel, Switzerland) · 2022Article
- Application of chitosan-based nanoparticles in skin wound healing.Asian journal of pharmaceutical sciences · 2022Review
- Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels.Scientific reports · 2021Article
- Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances.Journal of functional biomaterials · 2021Review
- Advances in Nanotechnology towards Development of Silver Nanoparticle-Based Wound-Healing Agents.International journal of molecular sciences · 2021Review
- Marine Polysaccharides for Wound Dressings Application: An Overview.Pharmaceutics · 2021Review
- Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications.Polymers · 2021Review
- Electrospun Nanofibers/Nanofibrous Scaffolds Loaded with Silver Nanoparticles as Effective Antibacterial Wound Dressing Materials.Pharmaceutics · 2021Review
- Nanotechnologies: An Innovative Tool to Release Natural Extracts with Antimicrobial Properties.Pharmaceutics · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, a mixture of poly(vinyl alcohol) (PVA) and chitosan oligosaccharides (COS) was electrospun with silver nanoparticles (AgNPs) to produce fibrous mats for use in wound healing. The AgNPs were reduced by COS prior to electrospinning or Ag(+) was reduced via ultraviolet irradiation in nanofibers. The morphologies of the PVA/COS/AgNO3 and PVA/COS-AgNP nanofibers were analyzed by scanning electron microscopy. Formation of the AgNPs was investigated by field emission transmission electron microscopy, ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. We also evaluated the biocompatibility of the nanofibers, particularly their cytotoxicity to human skin fibroblasts and potential to cause primary skin irritation. The in vitro antibacterial activity and in vivo wound healing capacity of the nanofibers were also investigated. The nanofibers had a smooth surface with an average diameter of 130-192 nm. The diameters of the AgNPs were in the range of 15-22 nm. The nanofibers significantly inhibited growth of Escherichia coli and Staphylococcus aureus bacteria. PVA/COS-AgNP nanofibers accelerated the rate of wound healing over that of the control (gauze). The results of our in vitro and in vivo animal experiments suggest that PVA/COS-AgNP nanofibers should be of greater interest than PVA/COS/AgNO3 nanofibers for clinical use as a bioactive wound dressing.
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