ReviewImmunologic research2013
Age effects on mouse and human B cells.
Review in Immunologic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Immune Memory in Aging: a Wide Perspective Covering Microbiota, Brain, Metabolism, and Epigenetics.Clinical reviews in allergy & immunology · 2022Review
- Transplantation of bone marrow cells from miR150 knockout mice improves senescence-associated humoral immune dysfunction and arterial stiffness.Metabolism: clinical and experimental · 2022Article
- Aging impairs arterial compliance via Klotho-mediated downregulation of B-cell population and IgG levels.Cellular and molecular life sciences : CMLS · 2022Article
- Type I IFN-dependent antibody response at the basis of sex dimorphism in the outcome of COVID-19.Cytokine & growth factor reviews · 2021Review
- Review
- Physical Activity and Nutritional Influence on Immune Function: An Important Strategy to Improve Immunity and Health Status.Frontiers in physiology · 2021Review
- Immune Phenotyping of Patients With Acute Vogt-Koyanagi-Harada Syndrome Before and After Glucocorticoids Therapy.Frontiers in immunology · 2021Article
- Article
- Aging of the Immune System: Research Challenges to Enhance the Health Span of Older Adults.Frontiers in aging · 2020Article
- Age-related Autoimmune Changes in Lacrimal Glands.Immune network · 2019Review
- CD27- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males.Immunity & ageing : I & A · 2019Article
- Immunosenescence and human vaccine immune responses.Immunity & ageing : I & A · 2019Review
- Does patient age influence anti-cancer immunity?Seminars in immunopathology · 2019Review
- Tristetraprolin Is Required for Alveolar Bone Homeostasis.Journal of dental research · 2018Article
- Assessing immune aging in HIV-infected patients.Virulence · 2017Review
- Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques.PloS one · 2017Article
- Article
- Do human B-lymphocytes avoid aging until 60 years?Oncotarget · 2016Article
- Obesity decreases B cell responses in young and elderly individuals.Obesity (Silver Spring, Md.) · 2016Article
- Transcriptome Analysis of B Cell Immune Functions in Periodontitis: Mucosal Tissue Responses to the Oral Microbiome in Aging.Frontiers in immunology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Our laboratory has contributed to the areas of B cell receptor (BCR) and pre-BCR gene identification and transcription and has focused on the problem of the aged immune system in mice and humans for the last 15 years. We have found biomarkers for the decrease in B cell function in aged mice and humans. These include decreases in immunoglobulin (Ig) class switch (e.g., IgM to IgG), decreases in the enzyme AID (activation-induced cytidine deaminase) and decreases in the transcription factor E47. The E47 mRNA stability is decreased in old B cells due to decreased phospho-MAPKinase and phospho-TTP (tristetraprolin). Inflammation, e.g., TNF-α, which increases with age, impacts B cells directly by increasing their TNF-α and NF-κB and leads to the above decreased pathway. Both class switch and affinity maturation are decreased in elderly responses to the influenza vaccine and biomarkers we have found (numbers and percentages of switched memory B cells and AID in stimulated B cells in culture) can predict a beneficial or decreased immune response to the vaccine. Current and future avenues to improve the humoral immune response in the elderly are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.