ArticleHistochemistry and cell biology2014
What neurons hide behind calretinin immunoreactivity in the human gut?
Article in Histochemistry and cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Age-Related Loss of GPR68 and Calretinin Immunoreactive Neurons Within the Mucosa, Not the Myenteric Plexus of Human Colon.British journal of biomedical science · 2026Article
- The human colon: Evidence for degenerative changes during aging and the physiological consequences.Neurogastroenterology and motility · 2025Review
- Surgical pathology of Hirschsprung disease (HSCR).World journal of pediatric surgery · 2025Review
- Classification of human enteric neurons.Histochemistry and cell biology · 2021Review
- Characterization of putative interneurons in the myenteric plexus of human colon.Neurogastroenterology and motility · 2021Article
- Calbindin D28k-Immunoreactivity in Human Enteric Neurons.International journal of molecular sciences · 2018Article
- A critical appraisal of the morphological criteria for diagnosing intestinal neuronal dysplasia type B.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- Downregulation of neuronal vasoactive intestinal polypeptide in Parkinson's disease and chronic constipation.Neurogastroenterology and motility · 2017Article
- The Histochemistry and Cell Biology pandect: the year 2014 in review.Histochemistry and cell biology · 2015Review
- Enteric plexuses of two choline-acetyltransferase transgenic mouse lines: chemical neuroanatomy of the fluorescent protein-expressing nerve cells.Brain research bulletin · 2015Article
- Architecture and Chemical Coding of the Inner and Outer Submucous Plexus in the Colon of Piglets.PloS one · 2015Article
- Chagasic megacolon: enteric neurons and related structures.Histochemistry and cell biology · 2014Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calretinin (CALR) is often used as an immunohistochemical marker for the histopathological diagnosis of human intestinal neuropathies. However, little is known about its distribution pattern with respect to specific human enteric neuron types. Prior studies revealed CALR in both myenteric and submucosal neurons, most of which colabel with choline acetyl transferase (ChAT). Here, we specified the chemical code of CALR-positive neurons in small and large intestinal wholemounts in a series of 28 patients. Besides other markers, we evaluated the labeling pattern of CALR in combination with vasoactive intestinal peptide (VIP). In colonic submucosa, CALR and VIP were almost completely colocalized in about three-quarters of all submucosal neurons. In the small intestinal submucosa, both the colocalization rate of CALR and VIP as well as the proportion of these neurons were lower (about one-third). In the myenteric plexus of both small intestine and colon, CALR amounted to 11 and 10 %, respectively, whereas VIP to 5 and 4 % of the whole neuron population, respectively. Colocalization of both markers was found in only 2 and 3 % of myenteric neurons, respectively. In section specimens, nerve fibers coreactive for CALR and VIP were found in the mucosa but not in the muscle coat. Summarizing the present and earlier results, CALR was found in at least one submucosal and two myenteric neuron populations. Submucosal CALR+/VIP+/ChAT± neurons innervate mucosal structures. Furthermore, CALR immunoreactivity in the myenteric plexus was observed in morphological type II (supposed primary afferent) and spiny type I (supposed inter- or motor-) neurons.
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