ArticleFish physiology and biochemistry1994
The carbonic anhydrase inhibitor in trout plasma: purification and its effect on carbonic anhydrase activity and the Root effect.
Article in Fish physiology and biochemistry, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 19 citations in OpenAlex.
- An atlas of plasma-accessible carbonic anhydrase availability in the model teleost, the rainbow trout.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- The effects of experimental anaemia on CO2 excretionin vitro in rainbow trout,Oncorhynchus mykiss.Fish physiology and biochemistry · 1996Article
- Investigation of the pseudobranch organ in rainbow trout (Oncorhyncus mykiss): endogenous substrates and activities of carbonic anhydrase, lactate dehydrogenase, and 3-hydroxy-acyl CoA dehydrogenase.Fish physiology and biochemistry · 1995Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plasma inhibitor of carbonic anhydrase (CA) from rainbow trout was purified using ion exchange chromatography. The inhibitor has a high isoelectric point value (pI>10). SDS-PAGE electrophoresis and gel filtration demonstrated that the inhibitor is a low molecular weight compound of about 6,000 daltons. The plasma inhibitor was more effective against gill CA than against blood CA in vitro, probably reflecting the presence of various CA-isoenzymes in red blood cells and gill tissue. The apparent Root effect, i.e., the impairment of the oxygen binding capacity of hemoglobin in red blood associated with increased blood PCO 2was counteracted by the plasma inhibitor, probably by acting on membrane-bound and/or cytosolic blood CA. This interaction may be of importance in adaptive mechanisms, e.g., during the acidemic phase, when the fish is being acclimated to hypercapnic conditions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.