ArticleJournal of materials science. Materials in medicine2014
Differentiation of human mesenchymal stem cells on plasma-treated polyetheretherketone.
Article in Journal of materials science. Materials in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
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Who cites it
22 citing papers in PubMed.
- Evaluation of osseointegration of plasma treated polyaryletherketone maxillofacial implants.Scientific reports · 2025Article
- Article
- A self-assembling graphene oxide coating for enhanced bactericidal and osteogenic properties of poly-ether-ether-ketone.Frontiers in bioengineering and biotechnology · 2024Article
- Bioactive Polyetheretherketone with Gelatin Hydrogel Leads to Sustained Release of Bone Morphogenetic Protein-2 and Promotes Osteogenic Differentiation.International journal of molecular sciences · 2023Article
- Composite-veneering of polyether-ether-ketone (PEEK): evaluating the effects of different surface modification methods on surface roughness, wettability, and bond strength.Lasers in medical science · 2023Article
- Surface Treatments of PEEK for Osseointegration to Bone.Biomolecules · 2023Review
- Surface Modifications of High-Performance Polymer Polyetheretherketone (PEEK) to Improve Its Biological Performance in Dentistry.Polymers · 2022Review
- Attachment and Osteogenic Potential of Dental Pulp Stem Cells on Non-Thermal Plasma and UV Light Treated Titanium, Zirconia and Modified PEEK Surfaces.Materials (Basel, Switzerland) · 2022Article
- Modification of polyetheretherketone (PEEK) physical features to improve osteointegration.Journal of Zhejiang University. Science. B · 2022Review
- Customized Barrier Membrane (Titanium Alloy, Poly Ether-Ether Ketone and Unsintered Hydroxyapatite/Poly-l-Lactide) for Guided Bone Regeneration.Frontiers in bioengineering and biotechnology · 2022Review
- In vitro osteogenesis of rat bone marrow mesenchymal cells on PEEK disks with heat-fixed apatite by COBMC musculoskeletal disorders · 2020Article
- Physico-Chemical Surface Modifications of Polyetheretherketone (PEEK) Using Extreme Ultraviolet (EUV) Radiation and EUV-Induced Nitrogen Plasma.Materials (Basel, Switzerland) · 2020Article
- Controlling stem cell fate using cold atmospheric plasma.Stem cell research & therapy · 2020Review
- Biologically Modified Polyether Ether Ketone as Dental Implant Material.Frontiers in bioengineering and biotechnology · 2020Review
- Three-Dimensionally-Printed Polyether-Ether-Ketone Implant with a Cross-Linked Structure and Acid-Etched Microporous Surface Promotes Integration with Soft Tissue.International journal of molecular sciences · 2019Article
- In Vitro Effect of Modified Polyetheretherketone (PEEK) Implant Abutments on Human Gingival Epithelial Keratinocytes Migration and Proliferation.Materials (Basel, Switzerland) · 2019Article
- PEEK with Reinforced Materials and Modifications for Dental Implant Applications.Dentistry journal · 2017Review
- Hydroxyapatite coating on PEEK implants: Biomechanical and histological study in a rabbit model.Materials science & engineering. C, Materials for biological applications · 2016Article
- Preparation Methods for Improving PEEK's Bioactivity for Orthopedic and Dental Application: A Review.International journal of biomaterials · 2016Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyetheretherketone (PEEK) generally exhibits physical and chemical characteristics that prevent osseointegration. To activate the PEEK surface, we applied oxygen and ammonia plasma treatments. These treatments resulted in surface modifications, leading to changes in nanostructure, contact angle, electrochemical properties and protein adhesion in a plasma power and process gas dependent way. To evaluate the effect of the plasma-induced PEEK modifications on stem cell adhesion and differentiation, adipose tissue-derived mesenchymal stem cells (adMSC) were seeded on PEEK specimens. We demonstrated an increased adhesion, proliferation, and osteogenic differentiation of adMSC in contact to plasma-treated PEEK. In dependency on the process gas (oxygen or ammonia) and plasma power (between 10 and 200 W for 5 min), varying degrees of osteogenic differentiation were induced. When adMSC were grown on 10 and 50 W oxygen and ammonia plasma-treated PEEK substrates they exhibited a doubled mineralization degree relative to the original PEEK. Thus plasma treatment of PEEK specimens induced changes in surface chemistry and topography and supported osteogenic differentiation of adMSC in vitro. Therefore plasma treated PEEK holds perspective for contributing to osseointegration of dental and orthopedic load-bearing PEEK implants in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.