ArticleJournal of assisted reproduction and genetics2014
Quality of embryos transferred and progesterone levels are the most important predictors of live birth after fresh embryo transfer: a retrospective cohort study.
Article in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- LH supplementation of ovarian stimulation protocols influences follicular fluid steroid composition contributing to the improvement of ovarian response in poor responder women.Scientific reports · 2020Trial
- Antibiotic Exposure and Early Reproductive Outcomes of In Vitro Fertilization (IVF) in a Chinese Couple-Based Preconception Cohort.Environment & health (Washington, D.C.) · 2026Article
- MicroRNAomic Analysis of Spent Media from Slow- and Fast-Growing Bovine Embryos Reveal Distinct Differences.Animals : an open access journal from MDPI · 2024Article
- Predicting personalized cumulative live birth rate after a complete in vitro fertilization cycle: an analysis of 32,306 treatment cycles in China.Reproductive biology and endocrinology : RB&E · 2024Article
- High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes inFrontiers in endocrinology · 2024Article
- Using feature optimization and LightGBM algorithm to predict the clinical pregnancy outcomes afterFrontiers in endocrinology · 2023Article
- Decreased embryo implantation in rabbits infected with Taenia pisiformis.Parasitology research · 2022Article
- Individualized embryo selection strategy developed by stacking machine learning model for better in vitro fertilization outcomes: an application study.Reproductive biology and endocrinology : RB&E · 2021Article
- Multifactor Prediction of Embryo Transfer Outcomes Based on a Machine Learning Algorithm.Frontiers in endocrinology · 2021Article
- Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2020Article
- ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells.Oxidative medicine and cellular longevity · 2019Article
- The curious case of premature luteinization.Journal of assisted reproduction and genetics · 2018Review
- Chromatin Protamination and Catsper Expression in Spermatozoa Predict Clinical Outcomes after Assisted Reproduction Programs.Scientific reports · 2017Article
- Embryo transfer simulation improves pregnancy rates and decreases time to proficiency in Reproductive Endocrinology and Infertility fellow embryo transfers.Fertility and sterility · 2017Article
- Serum progesterone trend after day of transfer predicts live birth in fresh IVF cycles.Journal of assisted reproduction and genetics · 2017Article
- Observational
- Does Unilateral Oocyte Retrieval due to Transvaginally Inaccessible Ovaries, Contrary to Common Beliefs, Affect IVF/ICSI Treatment Outcomes That Much?BioMed research international · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify the independent predictors of live birth following IVF, and to assess the role of cohort-specific parameters, including antral follicle count (AFC), the number of oocytes retrieved, the total number of embryos, and the total number of good-quality embryos, in fresh IVF cycles.
methodsA retrospective cohort study of 2,525 infertile women undergoing IVF between 2002 and 2007. The hypothesis that the number and quality of embryos transferred capture the effects previously attributed to cohort-specific variables was examined using mediation analysis and spline analysis. Independent predictors were identified by a bootstrap algorithm. Multivariable logistic regression was performed and the proportion of explained variation was measured to compare the relative importance of transfer-specific vs. cohort-specific predictors.
resultsThe number of good-quality embryos transferred and progesterone level on the day of hCG administration ranked as the two most important predictors of live birth. Prospects of pregnancy started to decrease after progesterone level exceeded 0.6 ng/ml. The achievement of live birth in a fresh IVF cycle is primarily determined by the number and quality of embryos transferred, rather than by embryo cohort-specific variables.
conclusionsThe associations between cohort-specific variables and live birth in a fresh IVF cycle are completely mediated by the quality of embryos transferred. Progesterone level on the day of hCG administration is an independent predictor of pregnancy and merits further investigation.
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