ArticleInflammation2014
Selenium inhibits LPS-induced pro-inflammatory gene expression by modulating MAPK and NF-κB signaling pathways in mouse mammary epithelial cells in primary culture.
Article in Inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Sodium Selenite Preconditioning Reprograms Mesenchymal Stem Cell Behavior Under Inflammatory Stress to Enhance Anti-Inflammatory Macrophage Responses.Biological trace element research · 2026Article
- Selenium: From Redox Signaling to Interactions with the Gut Microbiome.Biological trace element research · 2026Review
- Elucidating the Ameliorative Roles of Dietary Organic Selenium on the Mitigation of Exposure to Cadmium Stress in Stripped Mullet (Mugil cephalus): Exploring Growth Rate, Stress Biomarkers, Immune and Reproduction-Related Genes.Biological trace element research · 2026Article
- Selenium-enriched yeast improves gut health in broilers by modulating the gut microbiota-metabolites-intestinal mucosal immunity axis.Journal of animal science · 2026Article
- Biochemical assessment of selenium's cardiovascular protective effects in a lipopolysaccharide-induced damage in rats: Focus on oxidative stress markers and IL-6.Journal of cardiovascular and thoracic research · 2025Article
- Mesenchymal stem cells and their secretome modulate stress and enhance lipogenesis in bovine mammary epithelial cells.Stem cell research & therapy · 2025Article
- Selenium Yeast Attenuated Lipopolysaccharide-Induced Inflammation in Porcine Mammary Epithelial Cells by Modulating MAPK and NF-κB Signaling Pathways.Antioxidants (Basel, Switzerland) · 2025Article
- Synergistic Effect of Maternal Micronutrient Supplementation on ORFV DNA Vaccine Immune Response in a Pregnant Model.Biological trace element research · 2025Article
- Dietary Iron Overload Triggers Hepatic Metabolic Disorders and Inflammation in Laying Hen.Biological trace element research · 2025Article
- Selenium elicited an enhanced anti-inflammatory effect in primary bovine endometrial stromal cells with high cortisol background.BMC veterinary research · 2024Article
- Association of serum selenium with MASLD and liver fibrosis: A cross-sectional study.PloS one · 2024Article
- Article
- Enhancing bovine immune, antioxidant and anti-inflammatory responses with vitamins, rumen-protected amino acids, and trace minerals to prevent periparturient mastitis.Frontiers in immunology · 2023Review
- Associations of multiple toxic metal exposures with metabolic dysfunction-associated fatty liver disease: NHANES 2011-2018.Frontiers in nutrition · 2023Article
- Hydroxy-Selenomethionine, an Organic Selenium Source, Increases Selenoprotein Expression and Positively Modulates the Inflammatory Response of LPS-Stimulated Macrophages.Antioxidants (Basel, Switzerland) · 2022Article
- Influence of dietary vitamin E and selenium supplementation on broilers subjected to heat stress, Part II: oxidative stress, immune response, gut integrity, and intestinal microbiota.Poultry science · 2022Article
- Role of Selenium and Vitamins E and B9 in the Alleviation of Bovine Mastitis during the Periparturient Period.Antioxidants (Basel, Switzerland) · 2022Review
- Network pharmacology analysis and experimental study strategy reveals the potential mechanism of puerarin against rotavirus.Annals of translational medicine · 2022Article
- Novel organic selenium source hydroxy-selenomethionine counteracts the blood-milk barrier disruption and inflammatory response of mice under heat stress.Frontiers in immunology · 2022Article
- Selenium Deficiency via the TLR4/TRIF/NF-κB Signaling Pathway Leading to Inflammatory Injury in Chicken Spleen.Biological trace element research · 2021Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mastitis is characterized by an inflammation of the mammary gland of dairy animals and humans; this condition is one of the major causes of economic losses in dairy industries. Selenium (Se), a biological trace element, modulates the functions of many regulatory proteins in signal transduction and provides advantages for animals with inflammatory diseases, including mastitis. The current study aimed to assess the protective effects and the active mechanism of Na(2)SeO(3) against lipopolysaccharide (LPS)-induced inflammation in mouse mammary epithelial cells (MMECs). Our results showed that LPS-induced expressions of cyclooxygenase-2 and tumor necrosis factor-α significantly decreased after Se was supplemented to Se-deficient MMECs. Na(2)SeO(3) also suppressed LPS-induced nuclear factor-κB activation, inhibitory kappa B degradation, and ERK, JNK, and P38 phosphorylation in a dose-dependent manner. These results suggested that Se functions as an anti-inflammatory agent in mastitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.