Evidence map›Paper›PMID 24201900›Full record

ReviewKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2014

Pain after knee arthroplasty: an unresolved issue.

Irina Grosu, Patricia Lavand'homme, Emmanuel Thienpont

4 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 106 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 8 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02947321 nacompletednot on this mapstarted 2018, after this paper: background citation

GREAT Knee Pain Reduction Trial, Genicular Radiofrequency Ablation Efficacy in Achieving Total Knee Pain Reduction Trial

TypeinterventionalSponsorVanderbilt University Medical CenterRan2018 to 2020Enrolled60ConditionsKnee Arthroplasty, Total, Osteoarthritis, Radiologic Tibiofemoral OsteoarthritisArmsGenicular Nerve RFA, Sham Genicular Nerve RFA
NCT03339557 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Functional Outcome of Total Knee Replacement. Randomized Clinical Controlled Trial of Novel and Conventional Implants

TypeinterventionalSponsorCoxa, Hospital for Joint ReplacementRan2015 to 2021Enrolled240ConditionsOsteoarthritis, Knee, Arthroplasty, Total Knee ReplacementArmsNexGen, Persona, PFC
NCT06074744 narecruitingnot on this mapstarted 2023, after this paper: background citation

Subsartorial Saphenous Nerve Block (SSNB) Versus Femoral Nerve Block (FNB) in Primary Total Knee Arthroplasty (TKA) Combined With Infiltration Between Popliteal Artery and Capsule of the Knee (IPACK) - Where Are the Benefits?

TypeinterventionalSponsorLuzerner KantonsspitalRan2023 to 2026Enrolled144ConditionsJoint Diseases, Joint PainArmsSSNB + IPACK, FNB + IPACK
NCT07248072 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects of iPACK and Biceps Femoris Short Head (BiFeS) Blocks Combined With Adductor Canal Block on Quality of Recovery After Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind Clinical Trial

TypeinterventionalSponsorAtaturk UniversityRan2025 to 2026Enrolled74ConditionsKnee Osteoarthritis, Postoperative Pain Management, Total Knee ArthroplastyArmsAdductor Canal Block (ACB) Only, IPACK block, BiFeS Block
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 8 syntheses or guidelines pooled it, 251 citations in OpenAlex.

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  16. The role of a cryocompression device following total knee arthroplasty to assist in recovery: a randomised controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Irina GrosuDepartment of Anesthesiology, Cliniques Universitaires Saint Luc, Av. Hippocrate 10, 1200, Brussels, Belgium.
Patricia Lavand'homme
Emmanuel Thienpont
Cliniques Universitaires Saint-Luc · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDespite the recent advances in the understanding of pain mechanisms and the introduction of new drugs and new techniques in the postoperative management, pain after total knee arthroplasty (TKA) is still an unresolved issue. It affects the quality of life and rehabilitation of an important percentage of patients undergoing TKA. The aim of this narrative review was to give an overview on pain mechanisms and multimodal pain management.

methodsA review of all peer-reviewed articles on pain after knee arthroplasty was performed by two reviewers. Recent articles on incisional pain mechanisms were included because of their importance in the understanding of postsurgical pain. Search was performed in Pubmed, Cochrane and Google Scholar data bases.

resultsPostsurgical pain mechanisms are based on both local and systemic inflammatory reactions. Peri-operative pain management starts with the anaesthetic technique and resides on a multimodal analgesia regimen. New concepts, drugs and techniques have shown their efficacy in reducing the severity of acute postoperative pain and the risk of developing chronic pain after TKA.

conclusionThis narrative review offers a clear overview of pain mechanism after knee arthroplasty and an understanding on how multimodal pain management can reduce the intensity and duration of pain after knee arthroplasty.

Indexed as

Pain ManagementAcute PainAgedAged, 80 and overAnalgesiaArthroplasty, Replacement, KneeChronic PainFemaleHumansJoint DiseasesKneeKnee JointMalePostoperative Pain

Identifiers

PMID24201900
OpenAlexW2011562544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.