ReviewJournal of applied physiology (Bethesda, Md. : 1985)2014
Physiology in medicine: obstructive sleep apnea pathogenesis and treatment--considerations beyond airway anatomy.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05320952 (Effect of Upper Respiratory Muscle Strength Exercise on Sleep Apnea Using WellO2 Respiratory Exercise Device), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Upper Respiratory Muscle Strength Exercise on Sleep Apnea Using WellO2 Respiratory Exercise Device
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Models of anatomically based oropharyngeal rehabilitation with a multilevel approach for patients with obstructive sleep apnea: a meta-synthesis and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2020Pooled it
- Effects of respiratory muscle therapy on obstructive sleep apnea: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Pooled it
- Respiratory Safety of Lemborexant in Healthy Subjects: A Single-Dose, Randomized, Double-Blind, Placebo-Controlled, Crossover Study.Clinical drug investigation · 2021Trial
- Negative Expiratory Pressure Technique: An Awake Test to Measure Upper Airway Collapsibility in Adolescents.Sleep · 2015Trial
- Impact of CPAP treatment for a short period in moderate-to-severe OSAS patients: a randomized double-blind clinical trial.Brazilian journal of otorhinolaryngologyTrial
- Hyperbaric Oxygen Therapy and Its Physio-Mechanical Effects on Sleep Breathing Disorder: A Systematic Review.Pulmonary therapy · 2026Review
- Review
- Chronic Intermittent Hypoxia Exposure Induces a Unique Microglial Transcriptome in 5XFAD Mice.Molecular neurobiology · 2025Article
- Association Between Sleep Position, Obesity, and Obstructive Sleep Apnea Severity.Journal of personalized medicine · 2024Article
- Respiratory Dysfunction in Alzheimer's Disease-Consequence or Underlying Cause? Applying Animal Models to the Study of Respiratory Malfunctions.International journal of molecular sciences · 2024Review
- Sleep-Disordered Breathing and Chronic Respiratory Infections: A Narrative Review in Adult and Pediatric Population.International journal of molecular sciences · 2023Review
- Altitude and Breathing during Sleep in Healthy Persons and Sleep Disordered Patients: A Systematic Review.Sleep science (Sao Paulo, Brazil) · 2023Review
- Obstructive sleep apnea: transition from pathophysiology to an integrative disease model.Journal of sleep research · 2022Review
- Neural ventilatory drive decline as a predominant mechanism of obstructive sleep apnoea events.Thorax · 2022Article
- Fraction of apnea is associated with the required continuous positive airway pressure level and reflects upper airway collapsibility in patients with obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Breathing disturbances in Rett syndrome.Handbook of clinical neurology · 2022Review
- Systemic Administration of Tempol, a Superoxide Dismutase Mimetic, Augments Upper Airway Muscle Activity in Obese Zucker Rats.Frontiers in pharmacology · 2022Article
- A novel intraoral neuromuscular stimulation device for treating sleep-disordered breathing.Sleep & breathing = Schlaf & Atmung · 2021Article
- Alzheimer's Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link.Cells · 2021Review
- Assessment of respiratory effort with EMG extracted from ECG recordings during prolonged breath holds: Insights into obstructive apnea and extreme physiology.Physiological reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
We review evidence in support of significant contributions to the pathogenesis of obstructive sleep apnea (OSA) from pathophysiological factors beyond the well-accepted importance of airway anatomy. Emphasis is placed on contributions from neurochemical control of central respiratory motor output through its effects on output stability, upper airway dilator muscle activation, and arousability. In turn, we consider the evidence demonstrating effective treatment of OSA via approaches that address each of these pathophysiologic risk factors. Finally, a case is made for combining treatments aimed at both anatomical and ventilatory control system deficiencies and for individualizing treatment to address a patient's own specific risk factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.