Evidence map›Paper›PMID 24201696›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2014

Do ACE inhibitors improve the response to exercise training in functionally impaired older adults? A randomized controlled trial.

Deepa Sumukadas, Margaret Band, Suzanne Miller, Vera Cvoro, Miles Witham, Allan Struthers, Alex McConnachie, Suzanne M Lloyd, Marion McMurdo

Open access · bronzeAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
14.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Deepa SumukadasDivision of Cardiovascular and Diabetes Medicine, University of Dundee, UK. d.sumukadas@dundee.ac.uk.
Margaret BandDivision of Cardiovascular and Diabetes Medicine, University of Dundee, UK.
Suzanne MillerDepartment of Physiotherapy and.
Vera CvoroDepartment of Care of the Elderly, National Health Service Fife, Kirkcaldy, UK.
Miles WithamDivision of Cardiovascular and Diabetes Medicine, University of Dundee, UK.
Allan StruthersDivision of Cardiovascular and Diabetes Medicine, University of Dundee, UK.
Alex McConnachieRobertson Centre for Biostatistics, University of Glasgow, UK.
Suzanne M LloydRobertson Centre for Biostatistics, University of Glasgow, UK.
Marion McMurdoDivision of Cardiovascular and Diabetes Medicine, University of Dundee, UK.
University of Dundee · GBUniversity of Glasgow · GB

Funding

Chief Scientist Office CBZ/4/708Chief Scientist Office CZB/4/708
6 · The paper itself

Abstract

backgroundLoss of muscle mass and strength with ageing is a major cause for falls, disability, and morbidity in older people. Previous studies have found that angiotensin-converting enzyme inhibitors (ACEi) may improve physical function in older people. It is unclear whether ACEi provide additional benefit when added to a standard exercise training program. We examined the effects of ACEi therapy on physical function in older people undergoing exercise training.

methodsCommunity-dwelling people aged ≥ 65 years with functional impairment were recruited through general (family) practices. All participants received progressive exercise training. Participants were randomized to receive either 4 mg perindopril or matching placebo daily for 20 weeks. The primary outcome was between-group change in 6-minute walk distance from baseline to 20 weeks. Secondary outcomes included changes in Short Physical Performance Battery, handgrip and quadriceps strength, self-reported quality of life using the EQ-5D, and functional impairment measured using the Functional Limitations Profile.

resultsA total of 170 participants (n = 86 perindopril, n = 84 placebo) were randomized. Mean age was 75.7 (standard deviation [SD] 6.8) years. Baseline 6-minute walk distance was 306 m (SD 99). Both groups increased their walk distance (by 29.6 m perindopril, 36.4 m placebo group) at 20 weeks, but there was no statistically significant treatment effect between groups (-8.6m [95% confidence interval: -30.1, 12.9], p = .43). No statistically significant treatment effects were observed between groups for the secondary outcomes. Adverse events leading to withdrawal were few (n = 0 perindopril, n = 4 placebo).

interpretationACE inhibitors did not enhance the effect of exercise training on physical function in functionally impaired older people.

Indexed as

Activities of Daily LivingMobility LimitationAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsExercise TherapyExercise ToleranceFemaleFollow-Up StudiesHumansMaleMuscle StrengthPerindoprilPrognosisQuality of LifeRetrospective StudiesAngiotensin-Converting Enzyme InhibitorsPerindoprilACE inhibitorsExercise.Physical function

Identifiers

PMID24201696
PMCPMC4022094
OpenAlexW2150042773

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.