ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Expression of DNA methyltransferases is influenced by growth hormone in the long-living Ames dwarf mouse in vivo and in vitro.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
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- Metabolic reprogramming by Acly inhibition using SB-204990 alters glucoregulation and modulates molecular mechanisms associated with aging.Communications biology · 2023Article
- Sex-specific variations in global DNA methylation levels with age: a population-based exploratory study from North India.Frontiers in genetics · 2023Article
- L-Serine Influences Epigenetic Modifications to Improve Cognition and Behaviors in Growth Hormone-Releasing Hormone Knockout Mice.Biomedicines · 2022Article
- The epigenetic aging, obesity, and lifestyle.Frontiers in cell and developmental biology · 2022Review
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- Relationship between redox potential of glutathione and DNA methylation level in liver of newborn guinea pigs.Epigenetics · 2020Article
- Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice.Cell metabolism · 2020Article
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- Nutritional Epigenomics and Age-Related Disease.Current developments in nutrition · 2020Article
- Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production.Aging cell · 2020Article
- Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species.Aging cell · 2019Review
- Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research.GeroScience · 2019Review
- Review
- DNA Methylation Clocks in Aging: Categories, Causes, and Consequences.Molecular cell · 2018Review
- Age- and quality-dependent DNA methylation correlate with melanin-based coloration in a wild bird.Ecology and evolution · 2018Article
- Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction.Aging cell · 2018Article
- Revisiting the genomic hypomethylation hypothesis of aging.Annals of the New York Academy of Sciences · 2018Article
- Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys.Cell metabolism · 2018Article
- Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions.Genome biology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Methyltransferase expression and DNA methylation are linked to aging and age-related disease. We utilized 3-, 12-, and 24-month-old Ames dwarf and their wild-type siblings to examine the genotype and age-related differences in the expression of methyltransferase enzymes related to DNA methylation in the liver, glycine-N-methyltransferase and DNA methyltransferase (DNMT). We found that DNMT proteins and transcripts are differentially expressed in dwarf mice compared with wild-type siblings that can be attributed to age and/or genotype. However, DNMT1 protein expression is drastically reduced compared with wild-type controls at every age. DNMT3a protein levels coincide with differences observed in DNMT activity. Growth hormone appears to modulate expression of DNMT1 and 3a in dwarf liver tissue and primary hepatocytes. Therefore, growth hormone may contribute to age-related processes, DNA methylation, and, ultimately, longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.