Evidence map›Paper›PMID 24201674›Full record

ArticleObstetrics and gynecology2013

Use of guideline-based antibiotic prophylaxis in women undergoing gynecologic surgery.

Jason D Wright, Khalid Hassan, Cande V Ananth, Thomas J Herzog, Sharyn N Lewin, William M Burke, Yu-Shiang Lu, Alfred I Neugut, Dawn L Hershman

Abstract readComment
In one paragraph

Article in Obstetrics and gynecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Adherence to guidelines for surgical antibiotic prophylaxis: a review.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Inappropriate use of antibiotics in patients undergoing gynecologic surgery.Proceedings (Baylor University. Medical Center) · 2017
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jason D WrightDepartments of Obstetrics and Gynecology and Medicine and the Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, and the Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York, New York.
Khalid Hassan
Cande V Ananth
Thomas J Herzog
Sharyn N Lewin
William M Burke
Yu-Shiang Lu
Alfred I Neugut
Dawn L Hershman

Funding

The Influence of Hospital Variability on the Management of Cancer-Associated CompR01CA169121 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WRIGHT, JASON · 2013 to 2017
$1.8M
Determinants and risks of use and overuse of expensive oncology drugsR01CA134964 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HERSHMAN, DAWN · 2008 to 2011
$1.0M
NCI NIH HHS R01 CA134964NCI NIH HHS R01CA134964NCI NIH HHS R01 CA169121NCI NIH HHS R01CA169121-01A1
6 · The paper itself

Abstract

objectiveTo examine guideline-based use of prophylactic antibiotics in patients who underwent gynecologic surgery.

methodsWe identified women who underwent gynecologic surgery between 2003 and 2010. Procedures were stratified as antibiotic-appropriate (abdominal, vaginal, or laparoscopically assisted vaginal hysterectomy) or antibiotic-inappropriate (oophorectomy, cystectomy, tubal ligation, dilation and curettage, myomectomy, and tubal ligation). Antibiotic use was examined using hierarchical regression models.

resultsAmong 545,332 women who underwent procedures for which antibiotics were recommended, 87.1% received appropriate antibiotic prophylaxis, 2.3% received nonguideline-recommended antibiotics, and 10.6% received no prophylaxis. Use of antibiotics increased from 88.0% in 2003 to 90.7% in 2010 (P<.001). Among 491,071, who underwent operations for which antibiotics were not recommended, antibiotics were administered to 197,226 (40.2%) women. Use of nonguideline-based antibiotics also increased over time from 33.4% in 2003 to 43.7% in 2010 (P<.001). Year of diagnosis, surgeon and hospital procedural volume, and area of residence were the strongest predictors of guideline-based and nonguideline-based antibiotic use.

conclusionAlthough use of antibiotics is high for women who should receive antibiotics, antibiotics are increasingly being administered to women for whom the drugs are of unproven benefit. LEVEL OF EVIDENCE: : III.

Indexed as

Antibiotic ProphylaxisFemaleGynecologic Surgical ProceduresHumansSurgical Wound Infection

Identifiers

PMID24201674
PMCPMC4229050

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.