ArticleGenome biology and evolution2013
Multi-omics approaches to deciphering a hypervirulent strain of Campylobacter jejuni.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization bymSphere · 2025Article
- Analysis of the sheep (Ovis aries) vaginal microbiota preceding spontaneous abortion: a pilot study.Access microbiology · 2025Article
- Role ofInfection and immunity · 2020Article
- Campylobacter jejuni persistently colonizes gnotobiotic altered Schaedler flora C3H/HeN mice and induces mild colitis.FEMS microbiology letters · 2020Article
- Analysis of completeMicrobial genomics · 2020Article
- Genotyping of Campylobacter jejuni Isolates from Poultry by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR).Current microbiology · 2020Article
- Small Noncoding RNA CjNC110 Influences Motility, Autoagglutination, AI-2 Localization, Hydrogen Peroxide Sensitivity, and Chicken Colonization in Campylobacter jejuni.Infection and immunity · 2020Article
- The Anti-Microorganisms · 2019Article
- Genomic correlates of extraintestinal infection are linked with changes in cell morphology in Campylobacter jejuni.Microbial genomics · 2019Article
- Comparison of genomes and proteomes of four whole genome-sequenced Campylobacter jejuni from different phylogenetic backgrounds.PloS one · 2018Article
- Wide but Variable Distribution of a Hypervirulent Campylobacter jejuni Clone in Beef and Dairy Cattle in the United States.Applied and environmental microbiology · 2017Article
- Key Role of Capsular Polysaccharide in the Induction of Systemic Infection and Abortion by Hypervirulent Campylobacter jejuni.Infection and immunity · 2017Article
- RNAseq Reveals Complex Response ofFrontiers in microbiology · 2017Article
- Point mutations in the major outer membrane protein drive hypervirulence of a rapidly expanding clone of Campylobacter jejuni.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Genetic import and phenotype specific alleles associated with hyper-invasion in Campylobacter jejuni.BMC genomics · 2015Article
- A single nucleotide change in mutY increases the emergence of antibiotic-resistant Campylobacter jejuni mutants.The Journal of antimicrobial chemotherapy · 2015Article
- Antibiotic resistance modulation and modes of action of (-)-α-pinene in Campylobacter jejuni.PloS one · 2015Article
- Genetic diversity and antimicrobial susceptibility of Campylobacter jejuni isolates associated with sheep abortion in the United States and Great Britain.Journal of clinical microbiology · 2014Article
- Using gene expression to improve the power of genome-wide association analysis.Human heredity · 2014Article
- A comparative analysis of methylome profiles of Campylobacter jejuni sheep abortion isolate and gastroenteric strains using PacBio data.Frontiers in microbiology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Campylobacter jejuni clone SA recently emerged as the predominant cause of sheep abortion in the United States and is also associated with foodborne gastroenteritis in humans. A distinct phenotype of this clone is its ability to induce bacteremia and abortion. To facilitate understanding the pathogenesis of this hypervirulent clone, we analyzed a clinical isolate (IA3902) of clone SA using multi-omics approaches. The genome of IA3902 contains a circular chromosome of 1,635,045 bp and a circular plasmid of 37,174 bp. Comparative genomic analysis revealed that IA3902 is most closely related to C. jejuni NCTC11168, which is a reference strain and was previously shown to be non-abortifacient in pregnant animals. Despite the high genomic synteny and sequence homology, there are 12 variable regions (VRs) and 8,696 single-nucleotide polymorphisms and indels between the two genomes. Notably, the variable genes in the capsular polysaccharides biosynthesis and O-linked glycosylation loci of IA3902 are highly homogenous to their counterparts in C. jejuni subsp. doylei and C. jejuni G1, which are known to be frequently associated with bacteremia. Transcriptomic and proteomic profiles were conducted to compare IA3902 with NCTC11168, which revealed that the pathways of energy generation, motility, and serine utilization were significantly up-regulated in IA3902, whereas the pathways of iron uptake and proline, glutamate, aspartate, and lactate utilization were significantly down-regulated. These results suggest that C. jejuni clone SA has evolved distinct genomic content and gene expression patterns that modulate surface polysacharide structures, motilitiy, and metabolic pathways. These changes may have contributed to its hyper-virulence in abortion induction.
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