ArticleScientific reports2013
Antioxidant induces DNA damage, cell death and mutagenicity in human lung and skin normal cells.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 124 citations in OpenAlex.
- A randomized controlled trial of green tea catechins in protection against ultraviolet radiation-induced cutaneous inflammation.The American journal of clinical nutrition · 2015Trial
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- The Use of Nutritional Interventions to Enhance Genomic Stability in Mice and Delay Aging.Nutrients · 2026Review
- In silico and in vitro evaluation of drug-like properties and anticancer potential of novel 5-fluorouracil derivatives.Scientific reports · 2025Article
- Role of Nutritional Elements in Skin Homeostasis: A Review.Biomolecules · 2025Review
- Harmony in Motion: Unraveling the Nexus of Sports, Plant-Based Nutrition, and Antioxidants for Peak Performance.Antioxidants (Basel, Switzerland) · 2024Review
- Efficient inhibition of amyloid fibrillation and cytotoxicity of α-synuclein and human insulin using biosynthesized silver nanoparticles decorated by green tea polyphenols.Scientific reports · 2024Article
- Pure Epigallocatechin-3-gallate-Assisted Green Synthesis of Highly Stable Titanium Dioxide Nanoparticles.Materials (Basel, Switzerland) · 2024Article
- Recent Advances in the Synthesis of Antioxidant Derivatives: Pharmacological Insights for Neurological Disorders.Current topics in medicinal chemistry · 2024Review
- The Role of Polyphenolic Antioxidants from Tea and Rosemary in the Hydroxyl Radical Oxidation ofMolecules (Basel, Switzerland) · 2023Article
- Evaluation of The Effects of Carob (Journal of clinical research in pediatric endocrinology · 2023Article
- Possible Side Effects of Polyphenols and Their Interactions with Medicines.Molecules (Basel, Switzerland) · 2023Review
- Effect ofJournal of medicinal food · 2022Article
- In Vitro Antineoplastic and Antiviral Activity and In Vivo Toxicity ofMolecules (Basel, Switzerland) · 2021Article
- Antioxidant for Neurological Diseases and Neurotrauma and Bioengineering Approaches.Antioxidants (Basel, Switzerland) · 2021Review
- Towards Personalized Antioxidant Use in Female Infertility: Need for More Molecular and Clinical Studies.Biomedicines · 2021Review
- Induction of Premature Cell Senescence Stimulated by High Doses of Antioxidants Is Mediated by Endoplasmic Reticulum Stress.International journal of molecular sciences · 2021Article
- EGCG synergizes the therapeutic effect of irinotecan through enhanced DNA damage in human colorectal cancer cells.Journal of cellular and molecular medicine · 2021Article
- New combination chemotherapy of cisplatin with an electron-donating compound for treatment of multiple cancers.Scientific reports · 2021Article
- Antioxidative Stress: Inhibiting Reactive Oxygen Species Production as a Cause of Radioresistance and Chemoresistance.Oxidative medicine and cellular longevity · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Clinical trials have shown that antioxidant supplementation increased the risk of lung and skin cancers, but the underlying molecular mechanism is unknown. Here, we show that epigallocatechin gallate (EGCG) as an exemplary antioxidant induced significant death and DNA damage in human lung and skin normal cells through a reductive mechanism. Our results show direct evidence of reductive DNA damage in the cells. We found that EGCG was much more toxic against normal cells than H₂O₂ and cisplatin as toxic and cancer-causing agents, while EGCG at low concentrations (≤100 μM) increased slightly the lung cancer cell viability. EGCG induced DNA double-strand breaks and apoptosis in normal cells and enhanced the mutation frequency. These results provide a compelling explanation for the clinical results and unravel a new reductive damaging mechanism in cellular processes. This study therefore provides a fresh understanding of aging and diseases, and may lead to effective prevention and therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.