ArticleDevelopmental biology2014
Gβ1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Glypican 4 regulates planar cell polarity of endoderm cells by controlling the localization of Cadherin 2.Development (Cambridge, England) · 2021Article
- Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration.PloS one · 2021Article
- Overexpression of Lifeact-GFP Disrupts F-Actin Organization in Cardiomyocytes and Impairs Cardiac Function.Frontiers in cell and developmental biology · 2021Article
- Lamellipodia-like protrusions and focal adhesions contribute to collective cell migration in zebrafish.Developmental biology · 2021Article
- A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish.Journal of biomedical science · 2019Article
- Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system.Scientific reports · 2019Article
- Lpar2b Controls Lateral Line Tissue Size by Regulating Yap1 Activity in Zebrafish.Frontiers in molecular neuroscience · 2018Article
- Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Gβ1 is required for neutrophil migration in zebrafish.Developmental biology · 2017Article
- Cell migration during heart regeneration in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- A Subpopulation of Label-Retaining Cells of the Kidney Papilla Regenerates Injured Kidney Medullary Tubules.Stem cell reports · 2016Article
- The front and rear of collective cell migration.Nature reviews. Molecular cell biology · 2016Review
- Endoderm convergence controls subduction of the myocardial precursors during heart-tube formation.Development (Cambridge, England) · 2015Article
- Live imaging of endogenous protein dynamics in zebrafish using chromobodies.Development (Cambridge, England) · 2015Article
- Neural crest migration: trailblazing ahead.F1000prime reports · 2015Review
- The pros and cons of common actin labeling tools for visualizing actin dynamics during Drosophila oogenesis.Developmental biology · 2014Article
- There and back again: development and regeneration of the zebrafish lateral line system.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Collective cell migration is critical for normal development, tissue repair and cancer metastasis. Migration of the posterior lateral line primordium (pLLP) generates the zebrafish sensory organs (neuromasts, NMs). This migration is promoted by the leader cells at the leading edge of the pLLP, which express the G protein-coupled chemokine receptor Cxcr4b and respond to the chemokine Cxcl12a. However, the mechanism by which Cxc112a/Cxcr4b signaling regulates pLLP migration remains unclear. Here we report that signal transduction by the heterotrimeric G protein subunit Gβ1 is essential for proper pLLP migration. Although both Gβ1 and Gβ4 are expressed in the pLLP and NMs, depletion of Gβ1 but not Gβ4 resulted in an arrest of pLLP migration. In embryos deficient for Gβ1, the pLLP cells migrated in an uncoordinated fashion and were unable to extend protrusions at the leading front, phenocopying those in embryos deficient for Cxcl12a or Cxcr4b. A transplantation assay showed that, like Cxcr4b, Gβ1 is required only in the leader cells of the pLLP. Analysis of F-actin dynamics in the pLLP revealed that whereas wild-type leader cells display extensive actin polymerization in the direction of pLLP migration, counterparts defective for Gβ1, Cxcr4b or Cxcl12a do not. Finally, synergy experiments revealed that Gβ1 and Cxcr4b interact genetically in regulating pLLP migration. Collectively, our data indicate that Gβ1 controls migration of the pLLP, likely by acting downstream of the Cxcl12a/Cxcr4b signaling. This study also provides compelling evidence for functional specificity among Gβ isoforms in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.