ArticleCirculation. Cardiovascular genetics2013
Genetic influences on trajectories of systolic blood pressure across childhood and adolescence.
Article in Circulation. Cardiovascular genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Association Between Preeclampsia and Blood Pressure in Offspring: A Systematic Review and Meta-Analysis.Current hypertension reports · 2024Pooled it
- International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents.Circulation. Cardiovascular genetics · 2016Pooled it
- Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure.European heart journal · 2026Article
- Sex-stratified polygenic risk scores for coronary artery disease incidence: Insights from a 20-year cohort study.BMC cardiovascular disorders · 2026Article
- Body mass index modifies genetic susceptibility to high systolic blood pressure in adolescents and young adults: results from an 18-year longitudinal study.Journal of human hypertension · 2025Article
- A framework for conducting GWAS using repeated measures data with an application to childhood BMI.Nature communications · 2024Article
- Pediatric Blood Pressure and Cardiovascular Health in Adulthood.Current hypertension reports · 2024Review
- Polygenic risk scores associate with blood pressure traits across the lifespan.European journal of preventive cardiology · 2024Article
- A framework for conducting time-varying genome-wide association studies: An application to body mass index across childhood in six multiethnic cohorts.medRxiv : the preprint server for health sciences · 2024Article
- Genetic Variants Associated With Systolic Blood Pressure in Children and Adolescents.Journal of the American Heart Association · 2023Article
- Development of a genetic risk score to predict the risk of hypertension in European adolescents from the HELENA study.Frontiers in cardiovascular medicine · 2023Article
- Puberty timing and adiposity change across childhood and adolescence: disentangling cause and consequence.Human reproduction (Oxford, England) · 2020Article
- Heritability and genetic correlations of obesity indices with ambulatory and office beat-to-beat blood pressure in the Oman Family Study.Journal of hypertension · 2020Article
- Early-Life Predictors of Systolic Blood Pressure Trajectories From Infancy to Adolescence: Findings From Project Viva.American journal of epidemiology · 2019Article
- Data on trajectories of measures of cardiovascular health in the Avon Longitudinal Study of Parents and Children (ALSPAC).Data in brief · 2019Article
- Blood Pressure Trajectories from Childhood to Adolescence in Pediatric Hypertension.Korean circulation journal · 2019Review
- Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children.Wellcome open research · 2019Article
- Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence.Atherosclerosis · 2018Article
- Assessing genetic risk of hypertension at an early age: future research directions.Expert review of cardiovascular therapy · 2017Article
- Parental and offspring contribution of genetic markers of adult blood pressure in early life: The FAMILY study.PloS one · 2017Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBlood pressure (BP) tends to increase across childhood and adolescence, but the genetic influences on rates of BP change are not known. Potentially important genetic influences could include genetic variants identified in genome-wide association studies of adults as being associated with BP, height, and body mass index. Understanding the contribution of these genetic variants to changes in BP across childhood and adolescence could yield understanding into the life course development of cardiovascular risk. METHODS AND
resultsPooling data from 2 cohorts (the Avon Longitudinal Study of Parents and Children [n=7013] and the Western Australian Pregnancy Cohort [n=1459]), we examined the associations of allelic scores of 29 single-nucleotide polymorphisms (SNPs) for adult BP, 180 height SNPs, and 32 body mass index SNPs, with trajectories of systolic BP (SBP) from 6 to 17 years of age, using linear spline multilevel models. The allelic scores of BP and body mass index SNPs were associated with SBP at 6 years of age (per-allele effect sizes, 0.097 mm Hg [SE, 0.039 mm Hg] and 0.107 mm Hg [SE, 0.037 mm Hg]); associations with age-related changes in SBP between 6 and 17 years of age were of small magnitude and imprecisely estimated. The allelic score of height SNPs was only weakly associated with SBP changes. No sex or cohort differences in genetic effects were observed.
conclusionsAllelic scores of BP and body mass index SNPs demonstrated associations with SBP at 6 years of age with a similar magnitude but were not strongly associated with changes in SBP with age between 6 and 17 years. Further work is required to identify variants associated with changes with age in BP.
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