ArticleAJNR. American journal of neuroradiology2014
Diffusion imaging for tumor grading of supratentorial brain tumors in the first year of life.
Article in AJNR. American journal of neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Arterial spin labelling and diffusion-weighted imaging in paediatric brain tumours.NeuroImage. Clinical · 2019Pooled it
- Perfusion Showdown: Comparison of Multiple MRI Perfusion Techniques in the Grading of Pediatric Brain Tumors.AJNR. American journal of neuroradiology · 2025Article
- Advanced imaging techniques and non-invasive biomarkers in pediatric brain tumors: state of the art.Neuroradiology · 2024Review
- Intracranial Tumors in the First Year of Life.Advances and technical standards in neurosurgery · 2023Article
- Review
- Grading of Pediatric Intracranial Tumors: Are Intravoxel Incoherent Motion and Diffusional Kurtosis Imaging Superior to Conventional DWI?AJNR. American journal of neuroradiology · 2021Article
- Neuroimaging Appearance of Cerebral Malignant Epithelioid Glioneuronal Tumors in Children.AJNR. American journal of neuroradiology · 2020Article
- Longitudinal brain tumor segmentation prediction in MRI using feature and label fusion.Biomedical signal processing and control · 2020Article
- Can apparent diffusion coefficient values help distinguish between different types of pediatric brain tumors?European journal of radiology open · 2019Article
- Role of Multivoxel Intermediate TE 2D CSI MR Spectroscopy and 2D Echoplanar Diffusion Imaging in Grading of Primary Glial Brain Tumours.Journal of clinical and diagnostic research : JCDR · 2017Article
- Advanced MRI assessment to predict benefit of anti-programmed cell death 1 protein immunotherapy response in patients with recurrent glioblastoma.Neuroradiology · 2017Article
- Diffusion, Perfusion, and Histopathologic Characteristics of Desmoplastic Infantile Ganglioglioma.Journal of radiology case reports · 2016Review
- Contrast Leakage Patterns from Dynamic Susceptibility Contrast Perfusion MRI in the Grading of Primary Pediatric Brain Tumors.AJNR. American journal of neuroradiology · 2016Article
- Diffusion characteristics of pediatric pineal tumors.The neuroradiology journal · 2015Article
- MR imaging, apparent diffusion coefficient and histopathological features of desmoplastic infantile tumors-own experience and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Review
- Regional apparent diffusion coefficient values in 3rd trimester fetal brain.Neuroradiology · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeSupratentorial tumors in the first year of life are typically large and heterogeneous at presentation, making differentiation of these CNS neoplasms on pre-operative imaging difficult. We hypothesize that the ADC value can reliably differentiate high- versus low-grade supratentorial tumors in this patient population. MATERIALS AND
methodsA blinded review of ADC maps was performed on 19 patients with histologically proved supratentorial brain tumors diagnosed within the first year of life. Minimum ADC values obtained by region of interest from 2 neuroradiologists were averaged and compared with World Health Organization tumor grade. ADC values for the entire tumor were also obtained by use of a semi-automated histogram method and compared with World Health Organization tumor grade. Data were analyzed by use of Spearman ρ and Student t test, with a value of P < .05 considered statistically significant.
resultsFor the manual ADC values, a significant negative correlation was found between the mean minimum ADC and tumor grade (P = .0016). A significant difference was found between the mean minimum ADC of the low-grade (1.14 × 10(-3) mm(2)/s ± 0.30) and high-grade tumors (0.64 × 10(-3) mm(2)/s ± 0.28) (P = .0018). Likewise, the semi-automated method demonstrated a significant negative correlation between the lowest 5th (P = .0002) and 10th (P = .0009) percentile individual tumor ADC values and tumor grade, a significant difference between the mean 5th and 10th percentile ADC values of the low-grade and high-grade groups (P = .0028), and a significant positive correlation with values obtained by manual region-of-interest placement (P < .000001).
conclusionsADC maps can differentiate high- versus low-grade neoplasms for supratentorial tumors presenting in the first year of life, given the significant negative correlation between ADC values and tumor grade.
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