Evidence map›Paper›PMID 24200652›Full record

ArticleBiochimica et biophysica acta2014

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases.

M Cristina Kenney, Marilyn Chwa, Shari R Atilano, Payam Falatoonzadeh, Claudio Ramirez, Deepika Malik, Mohamed Tarek, Javier Cáceres Del Carpio, Anthony B Nesburn, David S Boyer and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 1 synthesis or guideline pooled it, 174 citations in OpenAlex.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

M Cristina KenneyGavin Herbert Eye Institute, Univ. of California Irvine, Irvine, CA, USA; Department of Pathology and Laboratory Medicine, Univ. of California Irvine, Irvine, CA, USA. Electronic address: mkenney@uci.edu.
Marilyn ChwaGavin Herbert Eye Institute, Univ. of California Irvine, Irvine, CA, USA.
Shari R AtilanoGavin Herbert Eye Institute, Univ. of California Irvine, Irvine, CA, USA.
Payam FalatoonzadehGavin Herbert Eye Institute, Univ. of California Irvine, Irvine, CA, USA.
Claudio RamirezGavin Herbert Eye Institute, Univ. of California Irvine, Irvine, CA, USA.
Deepika MalikGavin Herbert Eye Institute, Univ. of California Irvine, Irvine, CA, USA.
Mohamed TarekGavin Herbert Eye Institute, Univ. of California Irvine, Irvine, CA, USA.
Javier Cáceres Del CarpioGavin Herbert Eye Institute, Univ. of California Irvine, Irvine, CA, USA.
Anthony B NesburnGavin Herbert Eye Institute, Univ. of California Irvine, Irvine, CA, USA; Cedars-Sinai Medical Center, Los Angeles, CA, USA.
David S BoyerRetina-Vitreous Associates Medical Group, Beverly Hills, CA, USA.
Baruch D KuppermannGavin Herbert Eye Institute, Univ. of California Irvine, Irvine, CA, USA.
Marquis P VawterFunctional Genomics Laboratory, Department of Psychiatry and Human Behavior, Univ. of California Irvine, Irvine, CA, USA.
S Michal JazwinskiTulane Center for Aging, Tulane University, New Orleans, LA, USA.
Michael V MiceliTulane Center for Aging, Tulane University, New Orleans, LA, USA.
Douglas C WallaceChildren's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Nitin UdarGavin Herbert Eye Institute, Univ. of California Irvine, Irvine, CA, USA.
University of California, Irvine · USTulane University · USCedars-Sinai Medical Center · USChildren's Hospital of Pittsburgh · USRetina Vitreous Associates Medical Group · US

Funding

Mitochondrial Dysfunction In SchizophreniaR01MH085801 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI VAWTER, MARQUIS PHILIP · 2009 to 2020
$5.0M
CELLULAR AGING IN A YEAST MODEL SYSTEMR37AG006168 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI JAZWINSKI, S MICHAL · 1994 to 2016
$5.0M
CELLULAR AGING IN A YEAST MODEL SYSTEMR01AG006168 · NIA · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI JAZWINSKI, S MICHAL · 1986 to 1994
–
NIA NIH HHS AG006168NIA NIH HHS R37 AG006168NIMH NIH HHS R01 MH085801NIMH NIH HHS R01-MH-085801
6 · The paper itself

Abstract

The geographic origins of populations can be identified by their maternally inherited mitochondrial DNA (mtDNA) haplogroups. This study compared human cybrids (cytoplasmic hybrids), which are cell lines with identical nuclei but mitochondria from different individuals with mtDNA from either the H haplogroup or L haplogroup backgrounds. The most common European haplogroup is H while individuals of maternal African origin are of the L haplogroup. Despite lower mtDNA copy numbers, L cybrids had higher expression levels for nine mtDNA-encoded respiratory complex genes, decreased ATP (adenosine triphosphate) turnover rates and lower levels of reactive oxygen species production, parameters which are consistent with more efficient oxidative phosphorylation. Surprisingly, GeneChip arrays showed that the L and H cybrids had major differences in expression of genes of the canonical complement system (5 genes), dermatan/chondroitin sulfate biosynthesis (5 genes) and CCR3 (chemokine, CC motif, receptor 3) signaling (9 genes). Quantitative nuclear gene expression studies confirmed that L cybrids had (a) lower expression levels of complement pathway and innate immunity genes and (b) increased levels of inflammation-related signaling genes, which are critical in human diseases. Our data support the hypothesis that mtDNA haplogroups representing populations from different geographic origins may play a role in differential susceptibilities to diseases.

Indexed as

Adenosine TriphosphateAdultBlack PeopleCell LineCell ProliferationDNA, MitochondrialEnergy MetabolismGene DosageGene Expression ProfilingGenes, MitochondrialGenetic Predisposition to DiseaseHaplotypesHumansHybrid CellsLactatesMiddle AgedAdenosine TriphosphateDNA, MitochondrialLactatesReactive Oxygen SpeciesABIAdenosine triphosphateApplied BiosystemsARPE-19ATPC1sC3C4BCarbonyl Cyanide 4-trifluoromethoxy-phenylhydrazoneCFHComplement activationComplement component 1, s subcomponentComplement component 3Complement component 4BComplement factor HCybridDeoxyribonucleic acidDMEMDNADulbecco's modified Eagle's mediumECAREDTAElectron transport chainETCEthylenediaminetetracetic acidExtracellular acidification rateFCCPHaplogroupInnate immunityMaximal oxygen uptakeMicroMolarMitochondria encoded cytochrome BMitochondria encoded cytochrome oxidase 1Mitochondria encoded cytochrome oxidase 2Mitochondria encoded cytochrome oxidase 3Mitochondria encoded NADH dehydrogenase 1Mitochondria encoded NADH dehydrogenase 3Mitochondria encoded NADH dehydrogenase 5MitochondrionMT-CO1MT-CO2MT-CO3MT-CYBMT-ND1MT-ND3MT-ND5OCROxidative phosphorylationOXPHOSOxygen consumption rateQ-PCRQuantitative polymerase chain reactionRetinaRetinal pigmented epithelium cell lineSEMSingle nucleotide polymorphismsSNPsStandard error meanUCLAUniversity of California, Los AngelesVO2(max)μM

Identifiers

PMID24200652
PMCPMC4326177
OpenAlexW2133036751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.