SynthesisThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2014
Clinic visits in late-life depression trials: effects on signal detection and therapeutic outcome.
Synthesis in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Placebo response in antipsychotic clinical trials: a meta-analysis.JAMA psychiatry · 2014Pooled it
- Providing open-label placebos remotely-A randomized controlled trial in allergic rhinitis.PloS one · 2021Trial
- A Machine Learning Approach to Identifying Placebo Responders in Late-Life Depression Trials.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018Trial
- [Placebo effect in the treatment with antidepressants : Implications for the scientific evaluation and clinical use of pharmaceutical treatments of depression].Der Nervenarzt · 2025Review
- Working with patients' treatment expectations - what we can learn from homeopathy.Frontiers in psychology · 2024Review
- Specific and common mediators of gastrointestinal symptom improvement in patients undergoing education/support vs. cognitive behavioral therapy for irritable bowel syndrome.Journal of consulting and clinical psychology · 2021Article
- [The role of placebo and nocebo mechanisms in depressive diseases and their treatment].Der Nervenarzt · 2020Review
- Not Just Nonspecific Factors: The Roles of Alliance and Expectancy in Treatment, and Their Neurobiological Underpinnings.Frontiers in behavioral neuroscience · 2018Review
- Psychiatrists' Attitudes Toward Non-Pharmacologic Factors Within the Context of Antidepressant Pharmacotherapy.Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry · 2016Article
- Practising evidence-based medicine in an era of high placebo response: number needed to treat reconsidered.The British journal of psychiatry : the journal of mental science · 2016Article
- INFLUENCE OF STUDY DESIGN ON TREATMENT RESPONSE IN ANXIETY DISORDER CLINICAL TRIALS.Depression and anxiety · 2015Article
- Should antidepressant medication be used in the elderly?Expert review of neurotherapeutics · 2015Article
- Age and sex as moderators of the placebo response – an evaluation of systematic reviews and meta-analyses across medicine.Gerontology · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThis meta-analysis investigated how the supportive care provided in antidepressant clinical trials for late-life depression influences response and drop-out rates.
methodsMedline, PsycINFO, and PubMed were searched to identify trials contrasting antidepressants with placebo or active comparator in outpatients aged at least 60 years with major depressive disorder. Hierarchical linear modeling was used to determine whether treatment assignment (medication versus placebo), study type (placebo-controlled or comparator), study duration, and the number of study visits affected response and attrition rates.
resultsIn the response rate analysis, a significant interaction was found between study visits and treatment assignment (odds ratio [OR]: 0.89, t = -2.186, df = 36, p = 0.035), such that each additional visit over the grand mean for the sample increased average placebo response by 2.5% while not significantly affecting medication response. Controlling for other variables, the effect of this interaction was to dramatically decrease average medication versus placebo differences in trials having greater numbers of study visits. Neither the number of study visits (OR: 0.96, t = -0.468, df = 14, p = 0.646) nor the treatment × visits interaction (OR: 1.03, t = 0.463, df = 35, p = 0.645) influenced drop-out rates.
conclusionIncreased supportive care in the form of clinic visits leads to greater placebo but not antidepressant medication response in clinical trials for late-life depression. Less frequent visit schedules may increase average medication-placebo differences in randomized controlled trials without appreciably increasing drop-out rates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.