ArticleAcademic radiology2013
Assessment of trabecular bone yield and post-yield behavior from high-resolution MRI-based nonlinear finite element analysis at the distal radius of premenopausal and postmenopausal women susceptible to osteoporosis.
Article in Academic radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- A CombinedAnnals of biomedical engineering · 2026Article
- Using solid-state MRI and a double-tuned RF coil to quantify bone matrix and mineral densities in rat bones.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025Article
- Modular Hemipelvic Prosthesis Preserves Normal Biomechanics and Showed Good Compatibility: A Finite Element Analysis.Journal of functional biomaterials · 2024Article
- Article
- MRI-based mechanical competence assessment of bone using micro finite element analysis (micro-FEA): Review.Magnetic resonance imaging · 2022Review
- Impact of Genetic and Pharmacologic Inhibition of Myostatin in a Murine Model of Osteogenesis Imperfecta.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Article
- The Correlation between Osteoporosis and Blood Circulation Function Based on Magnetic Resonance Imaging.Journal of medical systems · 2019Article
- Patient-Specific Phantomless Estimation of Bone Mineral Density and Its Effects on Finite Element Analysis Results: A Feasibility Study.Computational and mathematical methods in medicine · 2019Article
- Micro-Finite Element Analysis of the Proximal Femur on the Basis of High-Resolution Magnetic Resonance Images.Current osteoporosis reports · 2018Review
- Accuracy of MRI-based finite element assessment of distal tibia compared to mechanical testing.Bone · 2018Article
- Biomechanics of the classic metaphyseal lesion: finite element analysis.Pediatric radiology · 2017Article
- MRI assessment of bone structure and microarchitecture.Journal of magnetic resonance imaging : JMRI · 2017Review
- Potential of PET-MRI for imaging of non-oncologic musculoskeletal disease.Quantitative imaging in medicine and surgery · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
RATIONALE AND
objectivesTo assess the performance of a nonlinear microfinite element model on predicting trabecular bone yield and post-yield behavior based on high-resolution in vivo magnetic resonance images via the serial reproducibility. MATERIALS AND
methodsThe nonlinear model captures material nonlinearity by iteratively adjusting tissue-level modulus based on tissue-level effective strain. It enables simulations of trabecular bone yield and post-yield behavior from micro magnetic resonance images at in vivo resolution by solving a series of nonlinear systems via an iterative algorithm on a desktop computer. Measures of mechanical competence (yield strain/strength, ultimate strain/strength, modulus of resilience, and toughness) were estimated at the distal radius of premenopausal and postmenopausal women (N = 20, age range 50-75) in whom osteoporotic fractures typically occur. Each subject underwent three scans (20.2 ± 14.5 days). Serial reproducibility was evaluated via coefficient of variation (CV) and intraclass correlation coefficient (ICC).
resultsNonlinear simulations were completed in an average of 14 minutes per three-dimensional image data set involving analysis of 61 strain levels. The predicted yield strain/strength, ultimate strain/strength, modulus of resilience, and toughness had a mean value of 0.78%, 3.09 MPa, 1.35%, 3.48 MPa, 14.30 kPa, and 32.66 kPa, respectively, covering a substantial range by a factor of up to 4. Intraclass correlation coefficient ranged from 0.986 to 0.994 (average 0.991); CV ranged from 1.01% to 5.62% (average 3.6%), with yield strain and toughness having the lowest and highest CV values, respectively.
conclusionsThe data suggest that the yield and post-yield parameters have adequate reproducibility to evaluate treatment effects in interventional studies within short follow-up periods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.