Evidence map›Paper›PMID 24200481›Full record

ArticleAcademic radiology2013

Prediction of near-term breast cancer risk based on bilateral mammographic feature asymmetry.

Maxine Tan, Bin Zheng, Pandiyarajan Ramalingam, David Gur

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Academic radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
8.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Machine learning and new insights for breast cancer diagnosis.The Journal of international medical research · 2024
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  19. Left-right analysis of mammary gland development in retinoid X receptor-α+/- mice.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Maxine TanSchool of Electrical and Computer Engineering, University of Oklahoma, 101 David L. Boren Blvd, Norman, OK 73019. Electronic address: maxinetyl@gmail.com.
Bin Zheng
Pandiyarajan Ramalingam
David Gur
University of Oklahoma · USUniversity of Pittsburgh · US

Funding

Mammographic Density and Tissue Asymmetry Based Breast Cancer Risk StratificationR01CA160205 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHENG, BIN · 2012 to 2015
$895k
NCI NIH HHS R01 CA160205NCI NIH HHS R01CA160205
6 · The paper itself

Abstract

RATIONALE AND

objectivesThe objective of this study is to investigate the feasibility of predicting near-term risk of breast cancer development in women after a negative mammography screening examination. It is based on a statistical learning model that combines computerized image features related to bilateral mammographic tissue asymmetry and other clinical factors. MATERIALS AND

methodsA database of negative digital mammograms acquired from 994 women was retrospectively collected. In the next sequential screening examination (12 to 36 months later), 283 women were diagnosed positive for cancer, 349 were recalled for additional diagnostic workups and later proved to be benign, and 362 remain negative (not recalled). From an initial pool of 183 features, we applied a Sequential Forward Floating Selection feature selection method to search for effective features. Using 10 selected features, we developed and trained a support vector machine classification model to compute a cancer risk or probability score for each case. The area under the receiver operating characteristic curve and odds ratios (ORs) were used as the two performance assessment indices.

resultsThe area under the receiver operating characteristic curve = 0.725 ± 0.018 was obtained for positive and negative/benign case classification. The ORs showed an increasing risk trend with increasing model-generated risk scores (from 1.00 to 12.34, between positive and negative/benign case groups). Regression analysis of ORs also indicated a significant increase trend in slope (P = .006).

conclusionsThis study demonstrates that the risk scores computed by a new support vector machine model involving bilateral mammographic feature asymmetry have potential to assist the prediction of near-term risk of women for developing breast cancer.

Indexed as

Breast NeoplasmsFeasibility StudiesFemaleFollow-Up StudiesHumansMammographyOdds RatioRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesRisk AssessmentROC CurveSupport Vector MachineBilateral mammographic feature asymmetrybreast cancercancer risk prediction modelcomputer-aided detection (CAD) of mammograms

Identifiers

PMID24200481
PMCPMC3856115
OpenAlexW1964901833

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.