Evidence map›Paper›PMID 24200416›Full record

ArticleSchizophrenia research2013

Association between cannabis use, psychosis, and schizotypal personality disorder: findings from the National Epidemiologic Survey on Alcohol and Related Conditions.

Glen P Davis, Michael T Compton, Shuai Wang, Frances R Levin, Carlos Blanco

Abstract read
In one paragraph

Article in Schizophrenia research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Prescribing smoked cannabis for chronic noncancer pain: preliminary recommendations.Canadian family physician Medecin de famille canadien · 2014
    Pooled it
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  13. Cannabis use, problem-gambling severity, and psychiatric disorders: Data from the National Epidemiological Survey on Alcohol and Related Conditions.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
    Article
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  18. Cannabis industry and medical cannabis clinics need regulation.Canadian family physician Medecin de famille canadien · 2019
    Article
  19. Canadian family physician Medecin de famille canadien · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Glen P DavisDepartment of Psychiatry, Division on Substance Abuse, Columbia University Medical Center/NYSPI, 1051 Riverside Drive, Unit 66, New York, NY 10032, United States. Electronic address: gpd2114@columbia.edu.
Michael T Compton
Shuai Wang
Frances R Levin
Carlos Blanco

Funding

Translational Clinical Research Fellowship on Substance Use DisordersT32DA007294 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Frances Rudnick Levin, Diana M Martinez · 1993 to 2026
$9.3M
Improving the Effectiveness of Treatment for Depression in HispanicsR01MH076051 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BLANCO, CARLOS · 2008 to 2012
$2.8M
Towards a Comprehensive Developmental Model of Substance Use DisordersR01DA019606 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI OLFSON, MARK · 2006 to 2016
$2.6M
Substance Abuse Treatment Development and Clinical Research MentoringK24DA029647 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEVIN, FRANCES RUDNICK · 2010 to 2019
$1.8M
First-Episode Psychosis and Pre-Onset Cannabis UseR01MH081011 · NIMH · GEORGE WASHINGTON UNIVERSITY · PI MYERS, NEELY A · 2008 to 2012
$1.7M
2/2 Gambling Addiction: Treatment Mediators and ModeratorsR01MH082773 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BLANCO, CARLOS · 2009 to 2012
$1.6M
Substance Use Comorbidity Care: Evidence-Based Stepped Strategies for DepressionR01DA023973 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI BLANCO, CARLOS · 2009 to 2010
$1.1M
Bridging Efficacy and Effectiveness in Drug Abuse TreatmentK02DA023200 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BLANCO, CARLOS · 2008 to 2012
$618k
NIDA NIH HHS DA007294NIDA NIH HHS DA019606NIDA NIH HHS DA023200NIDA NIH HHS DA023973NIDA NIH HHS K02 DA023200NIDA NIH HHS K24 DA029647NIDA NIH HHS R01 DA019606NIDA NIH HHS R01 DA023973NIDA NIH HHS T32 DA007294NIMH NIH HHS MH076051NIMH NIH HHS MH081011NIMH NIH HHS MH082773NIMH NIH HHS R01 MH076051NIMH NIH HHS R01 MH081011NIMH NIH HHS R01 MH082773
6 · The paper itself

Abstract

backgroundStudies to date showing an association between cannabis use and schizophrenia-spectrum disorders are of relatively small sample sizes with limitations in generalizability. The present study addresses this gap by examining the relationship between cannabis use and psychotic-like symptoms in a large representative community sample.

methodData were derived from the 2004-2005 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, Wave 2), a large, nationally representative sample of 34,653 adults from the United States population. We evaluated the association between lifetime cannabis use, psychosis, and schizotypal personality features.

resultsThe prevalence of psychosis and schizotypal personality disorder increased significantly with greater cannabis use in a dose-dependent manner. The associations between cannabis use and psychosis were 1.27 (95% CI 1.03-1.57) for lifetime cannabis use, 1.79 (95% CI 1.35-2.38) for lifetime cannabis abuse, and 3.69 (95% CI 2.49-5.47) for lifetime cannabis dependence. There was a similar dose-response relationship between the extent of cannabis use and schizotypal personality disorder (OR=2.02 for lifetime cannabis use, 95% CI 1.69-2.42; OR=2.83 for lifetime cannabis abuse, 95% CI 2.33-2.43; OR=7.32 for lifetime cannabis dependence, 95% CI 5.51-9.72). Likelihood of individual schizotypal features increased significantly with increased extent of cannabis use in a dose-dependent manner.

conclusionThis is the first population-based study to examine the association between lifetime cannabis use, psychosis, and schizotypal personality traits. These results add to evidence that cannabis use may be a risk factor for psychosis liability.

Indexed as

AdolescentAdultAge FactorsFemaleHealth SurveysHumansLogistic ModelsMaleMarijuana AbuseMiddle AgedPsychiatric Status Rating ScalesRetrospective StudiesSchizophreniaSchizotypal Personality DisorderYoung AdultCannabisEpidemiologyNESARCPsychosisSchizotypal

Identifiers

PMID24200416
PMCPMC3877688

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.