ArticleThe American journal of drug and alcohol abuse2013
Functional connectivity and cannabis use in high-risk adolescents.
Article in The American journal of drug and alcohol abuse, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Emotion regulation in substance use disorders: a systematic review and meta-analysis.Addiction (Abingdon, England) · 2023Pooled it
- Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature.Psychopharmacology · 2022Pooled it
- Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis.JAMA psychiatry · 2018Pooled it
- Relationship between fMRI response during a nonverbal memory task and marijuana use in college students.Drug and alcohol dependence · 2018Trial
- Associations Between Youth Marijuana and Alcohol Use, Neurocognitive Performance, and Triple-Network Resting-State Connectivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Long-Acting Naltrexone Restores Network Connectivity in Subjects With Comorbid Cannabis and Opioid Use Disorder.Addiction biology · 2026Article
- Long-acting naltrexone restores network connectivity in subjects with co-morbid cannabis and opioid use disorder.bioRxiv : the preprint server for biology · 2025Article
- Chronic ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Article
- A Review of Historical Context and Current Research on Cannabis Use in India.Indian journal of psychological medicine · 2023Article
- Effects of cannabinoid exposure on short-term memory and medial orbitofrontal cortex function and chemistry in adolescent female rhesus macaques.Frontiers in neuroscience · 2022Article
- Behavioral and brain signatures of substance use vulnerability in childhood.Developmental cognitive neuroscience · 2020Article
- Intrinsic Frontolimbic Connectivity and Mood Symptoms in Young Adult Cannabis Users.Frontiers in public health · 2019Article
- Longitudinal Alterations in Prefrontal Resting Brain Connectivity in Non-Treatment-Seeking Young Adults With Cannabis Use Disorder.Frontiers in psychiatry · 2019Article
- Working memory capacity and addiction treatment outcomes in adolescents.The American journal of drug and alcohol abuse · 2018Article
- Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults.Addiction (Abingdon, England) · 2017Article
- Nucleus accumbens functional connectivity at age 20 is associated with trajectory of adolescent cannabis use and predicts psychosocial functioning in young adulthood.Addiction (Abingdon, England) · 2017Article
- Regular cannabis and alcohol use is associated with resting-state time course power spectra in incarcerated adolescents.Drug and alcohol dependence · 2017Article
- Orbitofrontal and caudate volumes in cannabis users: a multi-site mega-analysis comparing dependent versus non-dependent users.Psychopharmacology · 2017Article
- Building smart cannabis policy from the science up.The International journal on drug policy · 2017Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAdolescence is a unique neurodevelopmental period when regions of the brain most able to assess risk and reward are still in development. Cannabis use during adolescence has been associated with persistent negative outcomes. Although measures of resting brain activity are useful in assessing functional connectivity, such measures have not been broadly applied in adolescent cannabis-users.
objectivesThe goal of the present study was to analyze the associations between cannabis use and resting brain activity in a sample of high-risk adolescents.
methodsEighty-two high-risk youth between 14-18 years old were recruited from a juvenile justice day program. Youth completed a brief neurocognitive battery including assessments of cannabis use and a 5-minute resting functional magnetic resonance imaging (fMRI) scan. Intrinsic connectivity networks were extracted using the GIFT toolbox. Brain activity in a fronto-temporal network was compared in youth with high cannabis use vs. low cannabis use using an independent-samples t-test with alcohol use entered as a covariate.
resultsAnalysis revealed two elements within the fronto-temporal network related to cannabis use: one in middle frontal gyrus related to high cannabis use, and one in middle temporal gyrus related to low cannabis use. Only the frontal source survived application of a cluster size threshold and was significant at p < 0.005.
conclusionsThese results are consistent with patterns of activity in adult cannabis-users. The observed effect may reflect either pre-existing risk factors or near-term consequences of cannabis use. Prevention and intervention strategies that address fronto-temporal functioning may be particularly helpful in this population.
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Registered trials
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