ArticleGenome biology2013
Metabolic reprogramming by viruses in the sunlit and dark ocean.
Article in Genome biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers.
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Who cites it
141 citing papers in PubMed, 296 citations in OpenAlex.
- Diversity of Antarctic sea ice and under-ice seawater RNA viruses.Applied and environmental microbiology · 2026Article
- Bacteriophage replication strategies are associated with organic matter energy content on coral reefs.mSystems · 2026Article
- Bacteriophages in the Rhizosphere: Roles in Nutrient Cycling, Bacterial Community Structure, and Animal-Mediated Dispersal.MicrobiologyOpen · 2026Review
- Synergistic Effects of Viruses and Environmental Gradients on Carbon Cycling in a River Ecosystem.Biology · 2026Article
- Diversity and ecological roles of hidden viral players in groundwater microbiomes.Nature communications · 2026Article
- Isolation and characterization of TayeBlu, a novel bacteriophage ofMicrobiology spectrum · 2026Article
- Ecosystem health shapes viral ecology in peatland soils.Nature microbiology · 2026Article
- Virus-encoded metabolism may support environmental stress adaptation of microbial hosts in an estuarine hypoxic zone.Frontiers in microbiology · 2026Article
- Viral Dark Matter: Illuminating Protein Function, Ecology, and Biotechnological Promises.Biochemistry · 2025Review
- Discarded diversity: novel megaphages, auxiliary metabolic genes, and virally encoded CRISPR-Cas systems in landfills.Virology journal · 2025Article
- Genomic diversity and global distribution of four new prasinoviruses from the tropical north Pacific.Microbiology spectrum · 2025Article
- Tracking putativemSystems · 2025Article
- Central carbon metabolism switching in lytic versus temperate coral reef viral communities.bioRxiv : the preprint server for biology · 2025Article
- A call for caution in the biological interpretation of viral auxiliary metabolic genes.Nature microbiology · 2025Review
- Viral Dark Matter: Illuminating Protein Function, Ecology, and Biotechnological Promises.ArXiv · 2025Article
- Functional and evolutionary characterization of potential auxiliary metabolic genes of the global RNA virome.iMetaOmics · 2025Article
- Bacteriophage-driven microbial phenotypic heterogeneity: ecological and biogeochemical importance.NPJ biofilms and microbiomes · 2025Review
- Expanding the potential soil carbon sink: unraveling carbon sequestration accessory genes in vermicompost phages.Applied and environmental microbiology · 2025Article
- The Role of Quorum Sensing in Phage Lifecycle Decision: A Switch Between Lytic and Lysogenic Pathways.Viruses · 2025Review
- Ecological features of microbial community linked to stochastic and deterministic assembly processes in acid mine drainage.Applied and environmental microbiology · 2025Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMarine ecosystem function is largely determined by matter and energy transformations mediated by microbial community interaction networks. Viral infection modulates network properties through mortality, gene transfer and metabolic reprogramming.
resultsHere we explore the nature and extent of viral metabolic reprogramming throughout the Pacific Ocean depth continuum. We describe 35 marine viral gene families with potential to reprogram metabolic flux through central metabolic pathways recovered from Pacific Ocean waters. Four of these families have been previously reported but 31 are novel. These known and new carbon pathway auxiliary metabolic genes were recovered from a total of 22 viral metagenomes in which viral auxiliary metabolic genes were differentiated from low-level cellular DNA inputs based on small subunit ribosomal RNA gene content, taxonomy, fragment recruitment and genomic context information. Auxiliary metabolic gene distribution patterns reveal that marine viruses target overlapping, but relatively distinct pathways in sunlit and dark ocean waters to redirect host carbon flux towards energy production and viral genome replication under low nutrient, niche-differentiated conditions throughout the depth continuum.
conclusionsGiven half of ocean microbes are infected by viruses at any given time, these findings of broad viral metabolic reprogramming suggest the need for renewed consideration of viruses in global ocean carbon models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.