ArticleBiological psychiatry2014
Neuroanatomical abnormalities and cognitive impairments are shared by adults with attention-deficit/hyperactivity disorder and their unaffected first-degree relatives.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Assessing Inhibitory Control Deficits in Adult ADHD: A Systematic Review and Meta-analysis of the Stop-signal Task.Neuropsychology review · 2024Pooled it
- Gray matter abnormalities in Tourette Syndrome: a meta-analysis of voxel-based morphometry studies.Translational psychiatry · 2021Pooled it
- Classification of familial and non-familial ADHD using auto-encoding network and binary hypothesis testing.Brain research bulletin · 2026Article
- The role of psychopharmacology and cognitive neuroscience in understanding the brain in the treatment of psychiatric disorders and neurological diseases for the benefit of society.Journal of psychopharmacology (Oxford, England) · 2026Article
- Discovery of disrupted sustained attention and altered functional connectivity in far-from-onset Huntington's disease gene-expanded young adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- White Matter Microstructural Abnormalities in Children with Familial vs. Non-Familial Attention-Deficit/Hyperactivity Disorder (ADHD).Biomedicines · 2025Article
- Understanding vigilance and its decrement: theoretical, contextual, and neural insights.Frontiers in cognition · 2025Review
- Distinct structural brain network properties in children with familial versus non-familial attention-deficit/hyperactivity disorder (ADHD).Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Risk of traumatic brain injury among patients with ADHD and their unaffected siblings.Pediatric research · 2024Article
- Exploring decision-making performance in young adults with mental health disorders: a comparative study using the Cambridge gambling task.Psychological medicine · 2024Article
- Attentional problems occur across multiple psychiatric disorders and are not specific for ADHD.CNS spectrums · 2023Article
- Distinct Thalamic and Frontal Neuroanatomical Substrates in Children with Familial vs. Non-Familial Attention-Deficit/Hyperactivity Disorder (ADHD).Brain sciences · 2022Article
- Gray matter volumetric correlates of attention deficit and hyperactivity traits in emerging adolescents.Scientific reports · 2022Article
- Altered dynamic functional architecture in type 2 diabetes mellitus.Frontiers in endocrinology · 2022Article
- Sex Differences in Neuropsychological Functioning are Domain-Specific in Adolescent and Young Adult Regular Cannabis Users.Journal of the International Neuropsychological Society : JINS · 2021Article
- Article
- Shared alterations in resting-state brain connectivity in adults with attention-deficit/hyperactivity disorder and their unaffected first-degree relatives.Psychological medicine · 2021Article
- "Hot" and "Cold" Cognition in Users of Club Drugs/Novel Psychoactive Substances.Frontiers in psychiatry · 2021Article
- The Role of Frontal and Occipital Cortices in Processing Sustained Visual Attention in Young Adults with Attention-Deficit/Hyperactivity Disorder: A Functional Near-Infrared Spectroscopy Study.Neuroscience bulletin · 2020Article
- Frontal volume as a potential source of the comorbidity between attention-deficit/hyperactivity disorder and reading disorders.Behavioural brain research · 2020Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAttention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder, yet the search for genes with a definitive role in its etiology has been elusive. Deconstructing the disorder in its endophenotypic traits, where the variance is thought to be associated with a fewer number of genes, should boost the statistical power of molecular genetic studies and clarify the pathophysiology of ADHD. In this study, we tested for neuroanatomical and cognitive endophenotypes in a group of adults with ADHD, their unaffected first-degree relatives, and typically developing control subjects.
methodsSixty participants, comprising 20 adults with ADHD, 20 unaffected first-degree relatives, and 20 typically developing control subjects matched for age and gender undertook structural magnetic resonance imaging scans. Voxel-based morphometry with DARTEL was performed to obtain regional gray and white matter volumes. General linear analyses of the volumes of brain regions, adjusting for age and total intracranial volume, were used to compare groups. Sustained attention and response inhibition were also investigated as cognitive endophenotypes.
resultsNeuroanatomical abnormalities in gray matter volume in the right inferior frontal gyrus and white matter volume in the caudal portion of the right inferior fronto-occipital fasciculus were shared between ADHD probands and their unaffected first-degree relatives. In addition, impairments in sustained attention were also found to be shared between ADHD patients and their relatives.
conclusionsCognitive impairments in sustained attention and neuroanatomical abnormalities in the right inferior frontal gyrus and the posterior part of right inferior fronto-occipital fasciculus are putative neurocognitive endophenotypes in adult ADHD.
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