ArticleJournal of neurogastroenterology and motility2013
Irritable bowel syndrome is associated with gastroesophageal reflux symptom but not erosive esophagitis.
Article in Journal of neurogastroenterology and motility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Pooled it
- The Association betweenInternational journal of environmental research and public health · 2020Pooled it
- The Potential Role of Intestinal Stem Cells and Microbiota for the Treatment of Colorectal Cancer.Advances in experimental medicine and biology · 2024Review
- The Prevalence and Risk Factors of Irritable Bowel Syndrome in Saudi Arabia in 2019.International journal of preventive medicine · 2022Article
- Impact of Overlapping Functional Gastrointestinal Disorders on the Quality of Life in Patients With Gastroesophageal Reflux Disease.Journal of neurogastroenterology and motility · 2021Review
- Overlapping of irritable bowel syndrome with erosive esophagitis and the performance of Rome criteria in diagnosing IBS in a clinical setting.Molecular medicine reports · 2019Article
- Belching in Irritable Bowel Syndrome: An Impedance Study.Journal of neurogastroenterology and motility · 2017Article
- Different effects of dietary factors on reflux esophagitis and non-erosive reflux disease in 11,690 Korean subjects.Journal of gastroenterology · 2017Article
- Central Obesity as a Risk Factor for Non-Erosive Reflux Disease.Yonsei medical journal · 2017Article
- Symptom burden and consulting behavior in patients with overlapping functional disorders in the US population.United European gastroenterology journal · 2016Article
- Not All Patients With Non-erosive Reflux Disease Share Psychological Distress as Main Mechanism of Disease.Journal of neurogastroenterology and motility · 2014Article
- Not All Patients With Non-erosive Reflux Disease Share Psychological Distress as Main Mechanism of Disease: Author's Reply.Journal of neurogastroenterology and motility · 2014Article
- Gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome: common overlapping gastrointestinal disorders.Annals of gastroenterologyReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsAlthough several studies have suggested overlaps between gastroesophageal reflux symptom and irritable bowel syndrome (IBS), the studies for the association between erosive esophagitis and IBS are rare. The aim of this study was to evaluate the association among IBS, non-erosive reflux disease (NERD), and erosive esophagitis.
methodsA total of 2,769 participants completed questionnaires and underwent esophagogastroduodenoscopy and colonoscopy. IBS was diagnosed by Rome III; NERD was defined as heartburn or acid regurgitation occurring at least once per week without erosive esophagitis. Erosive esophagitis was defined by Los Angeles classification. Psychological distress was evaluated with modified 4 dimensions from revised Hopkins symptom checklist 90.
resultsPsychological distress was associated with both IBS and NERD, but not with erosive esophagitis. IBS was associated with somatization (adjusted OR, 2.88; 95% CI, 1.55-5.36; P < 0.001), anxiety (adjusted OR, 2.82; 95% CI, 1.36-5.88; P = 0.005), and hostility (adjusted OR, 2.06; 95% CI, 1.10-3.87; P = 0.024) and NERD was associated with somatization (adjusted OR, 5.65; 95% CI, 2.92-10.98; P < 0.001) and anxiety (adjusted OR, 3.29; 95% CI, 1.47-7.34; P = 0.004). Erosive esophagitis was associated with somatization (adjusted OR, 2.69; 95% CI, 1.26-7.91; P < 0.001). Hiatal hernia and male sex were related with erosive esophagitis but not with IBS or NERD. H. pylori had an inverse relationship with erosive esophagitis, but had no association with IBS. Whereas IBS was positively associated with NERD (adjusted OR, 2.72; 95% CI, 1.84-4.03; P < 0.001), it had no association with erosive esophagitis.
conclusionsIBS shared many risk factors with NERD but not with erosive esophagitis. It partially explains why IBS was associated with NERD, but not with erosive esophagitis.
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Registered trials
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