ArticleNeural plasticity2013
The mechanisms of movement control and time estimation in cervical dystonia patients.
Article in Neural plasticity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- Comparison of Oropharyngeal Dysphagia Before and After Botulinum Toxin Injection in Cervical Dystonia.Dysphagia · 2023Article
- Role of cerebellar cortex in associative learning and memory in guinea pigs.Open life sciences · 2022Article
- Cognitive impairment in Chinese patients with cervical dystonia.Frontiers in neurology · 2022Article
- A cross-sectional study of walking, balance and upper limb assessment scales in people with cervical dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2021Observational
- Patients with Cervical Dystonia Demonstrated Decreased Cognitive Abilities and Visual Planning Compared to Controls.Movement disorders clinical practice · 2021Article
- Contribution of the Cerebellum and the Basal Ganglia to Language Production: Speech, Word Fluency, and Sentence Construction-Evidence from Pathology.Cerebellum (London, England) · 2021Review
- Affective and cognitive theory of mind in patients with cervical dystonia with and without tremor.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Pallidal Activity in Cervical Dystonia with and Without Head Tremor.Cerebellum (London, England) · 2020Article
- Quantitative but Not Qualitative Performance Changes in Predictive Motor Timing as a Result of Overtraining.Cerebellum (London, England) · 2020Article
- Neural Scaffolding as the Foundation for Stable Performance of Aging Cerebellum.Cerebellum (London, England) · 2019Article
- Sensorimotor Control in Dystonia.Brain sciences · 2019Review
- The role of sensory information in the pathophysiology of focal dystonias.Nature reviews. Neurology · 2019Review
- Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications.Cerebellum (London, England) · 2019Article
- Changes in sensorimotor network activation after botulinum toxin type A injections in patients with cervical dystonia: a functional MRI study.Experimental brain research · 2018Article
- Perceptual decisions based on previously learned information are independent of dopaminergic tone.Journal of neurophysiology · 2018Article
- Actual and Illusory Perception in Parkinson's Disease and Dystonia: A Narrative Review.Frontiers in neurology · 2018Review
- The mystery of the cerebellum: clues from experimental and clinical observations.Cerebellum & ataxias · 2018Review
- Cervical sensorimotor control in idiopathic cervical dystonia: A cross-sectional study.Brain and behavior · 2017Article
- Spatial and Temporal High Processing of Visual and Auditory Stimuli in Cervical Dystonia.Frontiers in neurology · 2017Article
- Cerebellum: An explanation for dystonia?Cerebellum & ataxias · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditionally, the pathophysiology of cervical dystonia has been regarded mainly in relation to neurochemical abnormities in the basal ganglia. Recently, however, substantial evidence has emerged for cerebellar involvement. While the absence of neurological "cerebellar signs" in most dystonia patients may be considered at least provoking, there are more subtle indications of cerebellar dysfunction in complex, demanding tasks. Specifically, given the role of the cerebellum in the neural representation of time, in the millisecond range, dysfunction to this structure is considered to be of greater importance than dysfunction of the basal ganglia. In the current study, we investigated the performance of cervical dystonia patients on a computer task known to engage the cerebellum, namely, the interception of a moving target with changing parameters (speed, acceleration, and angle) with a simple response (pushing a button). The cervical dystonia patients achieved significantly worse results than a sample of healthy controls. Our results suggest that the cervical dystonia patients are impaired at integrating incoming visual information with motor responses during the prediction of upcoming actions, an impairment we interpret as evidence of cerebellar dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.