ArticleFrontiers in aging neuroscience2013
Effects of aerobic fitness on aging-related changes of interhemispheric inhibition and motor performance.
Article in Frontiers in aging neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Priming cardiovascular exercise improves complex motor skill learning by affecting the trajectory of learning-related brain plasticity.Scientific reports · 2022Trial
- Changes in Cortical Activation Patterns in Language Areas following an Aerobic Exercise Intervention in Older Adults.Neural plasticity · 2017Trial
- Cardiorespiratory fitness is differentially associated with motor cortex laterality in middle-aged and older adults.Scientific reports · 2026Article
- Environmental enrichment: a neurostimulatory approach to aging and ischemic stroke recovery and rehabilitation.Biogerontology · 2025Review
- The influence of cardiovascular fitness and ventilatory efficiency on fMRI assessed cerebrovascular reactivity in older adults.Frontiers in physiology · 2025Article
- Article
- GABA, Aging and Exercise: Functional and Intervention Considerations.Neuroscience insights · 2024Review
- Article
- Reduced Interference and Serial Dependency Effects for Naming in Older but Not Younger Adults after 1 Hz rTMS of Right Pars Triangularis.Neurobiology of language (Cambridge, Mass.) · 2022Article
- Determinants of fine manual dexterity in adolescents and young adults with Down's syndrome.International journal of developmental disabilities · 2021Article
- Transcranial Magnetic Stimulation to Assess Exercise-Induced Neuroplasticity.Frontiers in neuroergonomics · 2021Review
- The Utility of Cerebrovascular Reactivity MRI in Brain Rehabilitation: A Mechanistic Perspective.Frontiers in physiology · 2021Review
- Does sedentary time increase in older adults in the days following participation in intense exercise?Aging clinical and experimental research · 2020Article
- TMS-induced silent periods: A review of methods and call for consistency.Journal of neuroscience methods · 2020Review
- Fitness Level Influences White Matter Microstructure in Postmenopausal Women.Frontiers in aging neuroscience · 2020Article
- Task-residual functional connectivity of language and attention networks.Brain and cognition · 2018Article
- Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-Limited Older Adults.Frontiers in aging neuroscience · 2018Article
- Effects of a 12-Week Aerobic Spin Intervention on Resting State Networks in Previously Sedentary Older Adults.Frontiers in psychology · 2018Article
- Advances in neurocognitive rehabilitation research from 1992 to 2017: The ascension of neural plasticity.Neuropsychology · 2017Review
- Physical activity modulates corticospinal excitability of the lower limb in young and old adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Physical fitness has been long associated with maintenance and improvement of motor performance as we age. In particular, measures of psychomotor speed and motor dexterity tend to be higher in physically fit aging adults as compared to their sedentary counterparts. Using functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS), we explored the patterns of neural activity that may, in part, account for differences between individuals of varying physical fitness levels. In this study, we enrolled both sedentary and physically fit middle age (40-60) and younger (18-30) adults and measured upper extremity motor performance during behavioral testing. In a follow-up session, we employed TMS and fMRI to assess levels of interhemispheric communication during unimanual tasks. Results show that increased physical fitness is associated with better upper extremity motor performance on distal dexterity assessments and increased levels of interhemispheric inhibition in middle age adults. Further, the functional correlates of changes of ipsilateral activity appears to be restricted to the aging process as younger adults of varying fitness levels do not differ in hemispheric patterns of activity or motor performance. We conclude that sedentary aging confers a loss of interhemispheric inhibition that is deleterious to some aspects of motor function, as early as midlife, but these changes can be mediated by chronic engagement in aerobic exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.