ReviewFrontiers in integrative neuroscience2013
Executive dysfunction in Parkinson's disease and timing deficits.
Review in Frontiers in integrative neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Beyond motor: a systematic review of multisensory integration deficits in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Pooled it
- Optimizing rehabilitation strategies in Parkinson's disease: a comparison of dual cognitive-walking treadmill training and single treadmill training.Scientific reports · 2024Trial
- Walking to your right music: a randomized controlled trial on the novel use of treadmill plus music in Parkinson's disease.Journal of neuroengineering and rehabilitation · 2019Trial
- Cognitive-Motor Duality in Human M1 and Cerebellum.Research square · 2026Article
- Glycolysis-enhancing αAlzheimer's research & therapy · 2026Article
- Communication between the medial frontal cortex and mediodorsal thalamus is required for timing performance in rats.Neurobiology of learning and memory · 2026Article
- Parkinson's and Alzheimer's disease impairs temporal precision.Research square · 2026Article
- The Temporal Scaffolding of Sensory Organization.Annual review of psychology · 2026Review
- Neural correlates of prospective memory in Parkinson's disease: a high-density EEG study.Frontiers in aging neuroscience · 2026Article
- Parkinson's disease and awareness of the passage of time: Perceived health, emotion, and self-transcendence.PloS one · 2026Article
- Cortical connectivity is associated with cognition across time in Parkinson's disease.Neuroimage. Reports · 2025Article
- Brain-Computer Interfaces in Parkinson's Disease Rehabilitation.Biomimetics (Basel, Switzerland) · 2025Review
- Gene Therapy Targeting GD3 Synthase Protects Against MPTP-Induced Parkinsonism and Executive Dysfunction.The European journal of neuroscience · 2025Article
- Article
- A double-blind, randomized, sham-controlled clinical trial of cerebellar intermittent theta burst stimulation for bipolar disorder: Safety, tolerability, mood and cognitive effects.Transcranial magnetic stimulation (2024) · 2025Article
- Insights into the interaction between time and reward prediction on the activity of striatal tonically active neurons: A pilot study in rhesus monkeys.Physiological reports · 2024Article
- Sex similarities and dopaminergic differences in interval timing.Behavioral neuroscience · 2024Article
- Identifying candidate genes associated with hippocampal dysfunction in a hemiparkinsonian rat model by transcriptomic profiling.Animal cells and systems · 2024Article
- Assessing of the Italian version of the Memory Strategy Test (TMS) in people with Parkinson disease: a preliminary descriptive psychometric study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Evoked mid-frontal activity predicts cognitive dysfunction in Parkinson's disease.Journal of neurology, neurosurgery, and psychiatry · 2023Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Patients with Parkinson's disease (PD) have deficits in perceptual timing, or the perception and estimation of time. PD patients can also have cognitive symptoms, including deficits in executive functions such as working memory, planning, and visuospatial attention. Here, we discuss how PD-related cognitive symptoms contribute to timing deficits. Timing is influenced by signaling of the neurotransmitter dopamine in the striatum. Timing also involves the frontal cortex, which is dysfunctional in PD. Frontal cortex impairments in PD may influence memory subsystems as well as decision processes during timing tasks. These data suggest that timing may be a type of executive function. As such, timing can be used to study the neural circuitry of cognitive symptoms of PD as they can be studied in animal models. Performance of timing tasks also maybe a useful clinical biomarker of frontal as well as striatal dysfunction in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.