ArticleFrontiers in cellular neuroscience2013
The adaptation of spike backpropagation delays in cortical neurons.
Article in Frontiers in cellular neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 22 citations in OpenAlex.
- Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum.Journal of neuroinflammation · 2023Article
- Loss of neuron network coherence induced by virus-infected astrocytes: a model study.Scientific reports · 2023Article
- Neuromodulation of Astrocytic KInternational journal of molecular sciences · 2021Article
- Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis.Cell death & disease · 2019Article
- Generating Brain Waves, the Power of Astrocytes.Frontiers in neuroscience · 2019Review
- Astrocytic modulation of cortical oscillations.Scientific reports · 2018Article
- Prolonged Incubation of Acute Neuronal Tissue for Electrophysiology and Calcium-imaging.Journal of visualized experiments : JoVE · 2017Article
- Article
- A neuromorphic implementation of multiple spike-timing synaptic plasticity rules for large-scale neural networks.Frontiers in neuroscience · 2015Article
- Extending the viability of acute brain slices.Scientific reports · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We measured the action potential backpropagation delays in apical dendrites of layer V pyramidal neurons of the somatosensory cortex under different stimulation regimes that exclude synaptic involvement. These delays showed robust features and did not correlate to either transient change in the stimulus strength or low frequency stimulation of suprathreshold membrane oscillations. However, our results indicate that backpropagation delays correlate with high frequency (>10 Hz) stimulation of membrane oscillations, and that persistent suprathreshold sinusoidal stimulation injected directly into the soma results in an increase of the backpropagation delay, suggesting an intrinsic adaptation of the backpropagating action potential (bAP), which does not involve any synaptic modifications. Moreover, the calcium chelator BAPTA eliminated the alterations in the backpropagation delays, strengthening the hypothesis that increased calcium concentration in the dendrites modulates dendritic excitability and can impact the backpropagation velocity. These results emphasize the impact of dendritic excitability on bAP velocity along the dendritic tree, which affects the precision of the bAP arrival at the synapse during specific stimulus regimes, and is capable of shifting the extent and polarity of synaptic strength during suprathreshold synaptic processes such as spike time-dependent plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.