ArticleJournal of virology2014
The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid.
Article in Journal of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Human alpha-defensin 5 stabilizes the enterovirus A71 capsid and blocks infection.bioRxiv : the preprint server for biology · 2026Article
- Mechanisms of AAV neutralization by human alpha-defensins.PLoS pathogens · 2025Article
- A Single Surface-Exposed Amino Acid Determines Differential Neutralization of AAV1 and AAV6 by Human Alpha-Defensins.Journal of virology · 2023Article
- The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV.International journal of molecular sciences · 2022Article
- VP4 Is a Determinant of Alpha-Defensin Modulation of Rotaviral Infection.Journal of virology · 2022Article
- Defensin-driven viral evolution.PLoS pathogens · 2020Article
- Article
- Antiviral Activities of Human Host Defense Peptides.Current medicinal chemistry · 2020Review
- Defensins: A Double-Edged Sword in Host Immunity.Frontiers in immunology · 2020Review
- α-Defensin HD5 StabilizesPathogens & immunity · 2019Article
- Alpha-defensin-dependent enhancement of enteric viral infection.PLoS pathogens · 2017Article
- Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis.Viruses · 2017Review
- Article
- Guardians of the Gut: Enteric Defensins.Frontiers in microbiology · 2017Review
- Thermodynamic instability of viral proteins is a pathogen-associated molecular pattern targeted by human defensins.Scientific reports · 2016Article
- Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions.Journal of virology · 2016Review
- Alpha-defensin HD5 inhibits furin cleavage of human papillomavirus 16 L2 to block infection.Journal of virology · 2015Article
- Delineation of interfaces on human alpha-defensins critical for human adenovirus and human papillomavirus inhibition.PLoS pathogens · 2014Article
- The human fetal glial cell line SVG p12 contains infectious BK polyomavirus.Journal of virology · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Progressive multifocal leukoencephalopathy (PML) is a fatal disease with limited treatment options, both clinically and in the research pipeline. Potential therapies would target and neutralize its etiologic agent, JC polyomavirus (JCPyV). The innate immune response to JCPyV infection has not been studied, and little is known about the initial host response to polyomavirus infection. This study examined the ability of a human alpha defensin, HD5, to neutralize JCPyV infection in human fetal glial cells. We show that HD5, by binding to the virion, blocks infection. The JCPyV-HD5 complexes bind to and enter host cells but are reduced in their ability to reach the endoplasmic reticulum (ER), where virions are normally uncoated. Furthermore, HD5 binding to the virion stabilizes the capsid and prevents genome release. Our results show that HD5 neutralizes JCPyV infection at an early postentry step in the viral life cycle by stabilizing the viral capsid and disrupting JCPyV trafficking. This study provides a naturally occurring platform for developing antivirals to treat PML and also expands on the known capabilities of human defensins.
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Registered trials
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