ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Axonal sprouting and formation of terminals in the adult cerebellum during associative motor learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Anatomy of Cerebro-cerebellar Circuits in Motor Control.Cerebellum (London, England) · 2026Review
- Impact of Sema3A Interference on Cerebellum-Dependent Motor Associative Learning and Memory.International journal of molecular sciences · 2026Article
- Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.Nature communications · 2025Article
- Purkinje cell ablation and Purkinje cell-specific deletion of Tsc1 in the developing cerebellum strengthen cerebellothalamic synapses.The Journal of physiology · 2024Article
- The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells.Cerebellum (London, England) · 2024Article
- Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum.Cerebellum (London, England) · 2024Review
- Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning.PLoS computational biology · 2024Article
- Cerebellar interpositus nucleus exhibits time-dependent errors and predictive responses.NPJ science of learning · 2024Article
- Synaptic mechanisms for associative learning in the cerebellar nuclei.Nature communications · 2023Article
- Neurophysiology of cerebellar ataxias and gait disorders.Clinical neurophysiology practice · 2023Review
- Synaptic pruning through glial synapse engulfment upon motor learning.Nature neuroscience · 2022Article
- The Theories of Gerbrandus Jelgersma (1859-1942) on the Function of the Cerebellum.Cerebellum (London, England) · 2022Article
- Learning and Stroke Recovery: Parallelism of Biological Substrates.Seminars in neurology · 2021Review
- Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation.Cell reports · 2021Article
- Bidirectional learning in upbound and downbound microzones of the cerebellum.Nature reviews. Neuroscience · 2021Review
- Population coding in the cerebellum: a machine learning perspective.Journal of neurophysiology · 2020Review
- A FN-MdV pathway and its role in cerebellar multimodular control of sensorimotor behavior.Nature communications · 2020Article
- Sleep deprivation directly following eyeblink-conditioning impairs memory consolidation.Neurobiology of learning and memory · 2020Article
- Review
- Cerebellar plasticity and associative memories are controlled by perineuronal nets.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plastic changes in the efficacy of synapses are widely regarded to represent mechanisms underlying memory formation. So far, evidence for learning-dependent, new neuronal wiring is limited. In this study, we demonstrate that pavlovian eyeblink conditioning in adult mice can induce robust axonal growth and synapse formation in the cerebellar nuclei. This de novo wiring is both condition specific and region specific because it does not occur in pseudoconditioned animals and is particularly observed in those parts of the cerebellar nuclei that have been implicated to be involved in this form of motor learning. Moreover, the number of new mossy fiber varicosities in these parts of the cerebellar nuclei is positively correlated with the amplitude of conditioned eyelid responses. These results indicate that outgrowth of axons and concomitant occurrence of new terminals may, in addition to plasticity of synaptic efficacy, contribute to the formation of memory.
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