ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Investigating axonal guidance with microdevice-based approaches.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Regulatory Effects of Gradient Microtopographies on Synapse Formation and Neurite Growth in Hippocampal Neurons.Journal of micromechanics and microengineering : structures, devices, and systems · 2022Article
- Understanding, engineering, and modulating the growth of neural networks: An interdisciplinary approach.Biophysics reviews · 2021Review
- Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth.Journal of visualized experiments : JoVE · 2019Article
- DAP5 increases axonal outgrowth of hippocampal neurons by enhancing the cap-independent translation of DSCR1.4 mRNA.Cell death & disease · 2019Article
- High-throughput three-dimensional chemotactic assays reveal steepness-dependent complexity in neuronal sensation to molecular gradients.Nature communications · 2018Article
- Combining FRET and optical tweezers to study RhoGTPases spatio-temporal dynamics upon local stimulation.Journal of biological methods · 2017Article
- Large-scale microfluidic gradient arrays reveal axon guidance behaviors in hippocampal neurons.Microsystems & nanoengineering · 2017Article
- Compartmentalized Microfluidic Platforms: The Unrivaled Breakthrough of In Vitro Tools for Neurobiological Research.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Microfluidic neurite guidance to study structure-function relationships in topologically-complex population-based neural networks.Scientific reports · 2016Article
- A mathematical model explains saturating axon guidance responses to molecular gradients.eLife · 2016Article
- Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients.Lab on a chip · 2015Article
- Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons.Neural development · 2015Article
- Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities.Small (Weinheim an der Bergstrasse, Germany) · 2015Article
- The discovery of the growth cone and its influence on the study of axon guidance.Frontiers in neuroanatomy · 2015Review
- Microfluidic systems for axonal growth and regeneration research.Neural regeneration research · 2014Article
- Gradient generation platforms: new directions for an established microfluidic technology.Lab on a chip · 2014Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The precise wiring of the nervous system relies on processes by which axons navigate in a complex environment and are guided by a concerted action of attractive and repulsive factors to reach their target. Investigating these guidance processes depends critically on our ability to control in space and time the microenvironment of neurons. The implementation of microfabrication techniques in cell biology now enables a precise control of the extracellular physical and chemical environment of cultured cells. However, microtechnology is only beginning to be applied in the field of axon guidance due to specific requirements of neuronal cultures. Here we review microdevices specifically designed to study axonal guidance and compare them with the conventional assays used to probe gradient sensing in cell biology. We also discuss how innovative microdevice-based approaches will enable the investigation of important systems-level questions on the gradient sensing properties of nerve cells, such as the sensitivity and robustness in the detection of directional signals or the combinatorial response to multiple cues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.