ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Complete muscle denervation triggers compensatory sprouting of a bystander tonic motor neuron iniScience · 2026Article
- Article
- Mitochondrial ROS and HIF-1α signaling mediate synaptic plasticity in the critical period.PLoS biology · 2025Article
- Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases.Frontiers in cellular neuroscience · 2022Article
- An improved catalogue of putative synaptic genes defined exclusively by temporal transcription profiles through an ensemble machine learning approach.BMC genomics · 2019Article
- cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.Cell reports · 2019Article
- Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Article
- Homeostatic plasticity can be induced and expressed to restore synaptic strength at neuromuscular junctions undergoing ALS-related degeneration.Human molecular genetics · 2017Article
- Transcriptional Reorganization ofFrontiers in molecular neuroscience · 2017Article
- The Drosophila KIF1A Homolog unc-104 Is Important for Site-Specific Synapse Maturation.Frontiers in cellular neuroscience · 2016Article
- Drosophila sodium channel mutations: Contributions to seizure-susceptibility.Experimental neurology · 2015Review
- Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach.BMC genomics · 2015Article
- Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Synaptic plasticity in a recurrent neural network for versatile and adaptive behaviors of a walking robot.Frontiers in neurorobotics · 2015Article
- Differential centrifugation-based biochemical fractionation of the Drosophila adult CNS.Nature protocols · 2014Article
- Acquisition of high-quality digital video of Drosophila larval and adult behaviors from a lateral perspective.Journal of visualized experiments : JoVE · 2014Article
- Drosophila melanogaster as a genetic model system to study neurotransmitter transporters.Neurochemistry international · 2014Review
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The fruit fly Drosophila melanogaster has been established as a premier experimental model system for neuroscience research. These organisms are genetically tractable, yet their nervous systems are sufficiently complex to study diverse processes that are conserved across metazoans, including neural cell fate determination and migration, axon guidance, synaptogenesis and function, behavioral neurogenetics, and responses to neuronal injury. For several decades, Drosophila neuroscientists have taken advantage of a vast toolkit of genetic and molecular techniques to reveal fundamental principles of neuroscience illuminating to all systems, including the first behavioral mutants from Seymour Benzer's pioneering work in the 1960s and 1970s, the cloning of the first potassium channel in the 1980s, and the identification of the core genes that orchestrate axon guidance and circadian rhythms in the 1990s. Over the past decade, new tools and innovations in genetic, imaging, and electrophysiological technologies have enabled the visualization, in vivo, of dynamic processes in synapses with unprecedented resolution. We will review some of the fresh insights into synaptic development, function, and plasticity that have recently emerged in Drosophila with an emphasis on the unique advantages of this model system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.