ArticleMolecular biology reports2014
The novel coding region SNPs of PPARGC1A gene and their associations with growth traits in Chinese native cattle.
Article in Molecular biology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Identification of Growth-Related Single-Nucleotide Polymorphisms in the cAMP-Dependent Protein Kinase Type I Regulatory Subunit-like Gene of the Oriental River Prawn,International journal of molecular sciences · 2026Article
- Exploring and Identifying Candidate Genes and Genomic Regions Related to Economically Important Traits in Hanwoo Cattle.Current issues in molecular biology · 2022Review
- Genome-Wide Association Studies for Growth Curves in Meat Rabbits Through the Single-Step Nonlinear Mixed Model.Frontiers in genetics · 2021Article
- Integrating Single-Step GWAS and Bipartite Networks Reconstruction Provides Novel Insights into Yearling Weight and Carcass Traits in Hanwoo Beef Cattle.Animals : an open access journal from MDPI · 2020Article
- Functional Partitioning of Genomic Variance and Genome-Wide Association Study for Carcass Traits in Korean Hanwoo Cattle Using Imputed Sequence Level SNP Data.Frontiers in genetics · 2018Article
- Association of ADIPOQ, OLR1 and PPARGC1A gene polymorphisms with growth and carcass traits in Nelore cattle.Meta gene · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The peroxisome proliferator-activated receptor gamma coactivator-1 alpha protein, encoded by the PPARGC1A gene, is a metabolic switch, which transcriptionally activates a complex pathway of mitochondrial biogenesis, lipid and glucose metabolism. Three SNPs (exon 3 c.396G>A, intron 9 c.1892 + 19C>T and exon 10 c.1971C>T) were found and identified in three Chinese native cattle breeds by PCR-SSCP, PCR-RFLP and DNA sequencing methods. All three populations had a low genetic diversity at SNP396 locus (PIC <0.25) while possessed a moderate genetic diversity at SNP1892 locus (0.25 < PIC < 0.5). Association study indicated that the synonymous mutation c.396G>A significantly associated with body weight and average daily gain in Nanyang cattle at the adult age (P < 0.05). Our investigation will not only extend the spectrum of genetic variation of bovine PPARGC1A gene, but also provide useful information for the marker assisted selection in beef cattle breeding program.
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