ArticleProceedings. Biological sciences2013
The evolution of bacterial mutation rates under simultaneous selection by interspecific and social parasitism.
Article in Proceedings. Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Effect of an antibiotic and a probiotic on phage communities in the swine gut microbiota.BMC research notes · 2025Article
- Hypermutability bypasses genetic constraints in SCV phenotypic switching in Pseudomonas aeruginosa biofilms.NPJ biofilms and microbiomes · 2025Article
- Host-pathogen coevolution drives innate immune response to Aphanomyces astaci infection in freshwater crayfish: transcriptomic evidence.BMC genomics · 2022Article
- Transposable temperate phages promote the evolution of divergent social strategies inProceedings. Biological sciences · 2019Article
- Mutation and Selection in Bacteria: Modelling and Calibration.Bulletin of mathematical biology · 2019Article
- Specificity of the DNA Mismatch Repair System (MMR) and Mutagenesis Bias in Bacteria.Molecular biology and evolution · 2018Article
- The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung.FEMS microbiology letters · 2017Review
- Sublethal streptomycin concentrations and lytic bacteriophage together promote resistance evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Adaptation to Parasites and Costs of Parasite Resistance in Mutator and Nonmutator Bacteria.Molecular biology and evolution · 2016Article
- Selection and Characterization of Phage-Resistant Mutant Strains of Listeria monocytogenes Reveal Host Genes Linked to Phage Adsorption.Applied and environmental microbiology · 2015Article
- Lytic phages obscure the cost of antibiotic resistance in Escherichia coli.The ISME journal · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many bacterial populations harbour substantial numbers of hypermutable bacteria, in spite of hypermutation being associated with deleterious mutations. One reason for the persistence of hypermutators is the provision of novel mutations, enabling rapid adaptation to continually changing environments, for example coevolving virulent parasites. However, hypermutation also increases the rate at which intraspecific parasites (social cheats) are generated. Interspecific and intraspecific parasitism are therefore likely to impose conflicting selection pressure on mutation rate. Here, we combine theory and experiments to investigate how simultaneous selection from inter- and intraspecific parasitism affects the evolution of bacterial mutation rates in the plant-colonizing bacterium Pseudomonas fluorescens. Both our theoretical and experimental results suggest that phage presence increases and selection for public goods cooperation (the production of iron-scavenging siderophores) decreases selection for mutator bacteria. Moreover, phages imposed a much greater growth cost than social cheating, and when both selection pressures were imposed simultaneously, selection for cooperation did not affect mutation rate evolution. Given the ubiquity of infectious phages in the natural environment and clinical infections, our results suggest that phages are likely to be more important than social interactions in determining mutation rate evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.