ArticlePsychopharmacology2014
Ultrasonic vocalizations: evidence for an affective opponent process during cocaine self-administration.
Article in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Dopamine receptor sensitivity, cocaine-induced behaviors, and Pavlovian conditioned approach in male rats.Psychopharmacology · 2026Article
- C57 and DBA mouse strains express distinct cocaine avoidance phenotypes in an operant runway independent of differences in striatal dynorphin-enkephalin balance.Psychopharmacology · 2026Article
- Alternating self-administration sessions of cocaine and heroin impact drug-related motivation and vocalisations in rats.Psychopharmacology · 2025Article
- Dopamine receptor sensitivity and Pavlovian conditioned approach.Research square · 2025Article
- The acoustic properties, syllable structure, and syllable sequences of ultrasonic vocalizations (USVs) during neonatal opioid withdrawal in FVB/N mouse substrains.Addiction neuroscience · 2025Article
- Shifted Balance Between Ventral Striatal Prodynorphin and Proenkephalin Biases Development of Cocaine Place Avoidance.Addiction biology · 2025Article
- Rapid appearance of negative emotion during oral fentanyl self-administration in male and female rats.Addiction biology · 2023Article
- Acquired Alterations in Nucleus Accumbens Responsiveness to a Cocaine-Paired Discriminative Stimulus Preceding Rats' Daily Cocaine Consumption.Addiction neuroscience · 2023Article
- Positive maternal affect during mother-litter interaction is reduced in new mother rats exhibiting a depression-like phenotype.Scientific reports · 2023Article
- Nucleus Accumbens Chemogenetic Inhibition Suppresses Amphetamine-Induced Ultrasonic Vocalizations in Male and Female Rats.Brain sciences · 2021Article
- Chronic Fentanyl Self-Administration Generates a Shift toward Negative Affect in Rats during Drug Use.Brain sciences · 2021Article
- Emergence of negative affect as motivation for drug taking in rats chronically self-administering cocaine.Psychopharmacology · 2020Article
- Cocaine abuse and midbrain circuits: Functional anatomy of hypocretin/orexin transmission and therapeutic prospect.Brain research · 2020Review
- DeepSqueak: a deep learning-based system for detection and analysis of ultrasonic vocalizations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Diazepam blocks 50 kHz ultrasonic vocalizations and stereotypies but not the increase in locomotor activity induced in rats by amphetamine.Psychopharmacology · 2018Article
- Suvorexant, an orexin/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine.Addiction biology · 2018Article
- Comparing rewarding and reinforcing properties between 'bath salt' 3,4-methylenedioxypyrovalerone (MDPV) and cocaine using ultrasonic vocalizations in rats.Addiction biology · 2018Article
- Stereoselective Differences between the Reinforcing and Motivational Effects of Cathinone-Derived 4-Methylmethcathinone (Mephedrone) In Self-Administering Rats.ACS chemical neuroscience · 2017Article
- Role of hypocretin/orexin receptor blockade on drug-taking and ultrasonic vocalizations (USVs) associated with low-effort self-administration of cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV) in rats.Psychopharmacology · 2017Article
- Automated acoustic analysis of 50-kHz ultrasonic vocalizations using template matching and contour analysis.The Journal of the Acoustical Society of America · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
rationalePreclinical models of cocaine addiction in the rodent have shown that cocaine induces both positive and negative affective states. These observations have led to the notion that the initial positive/euphoric state induced by cocaine administration may be followed by an opposing, negative process. In the rodent, one method for inferring positive and negative affective states involves measuring their ultrasonic vocalizations (USVs). Previous USV recordings from our laboratory suggested that the transition between positive and negative affect might involve decaying or sub-satiety levels of self-administered cocaine.
objectivesIn order to explicitly test the role of cocaine levels on these affective states, the present study examined USVs when calculated body levels of cocaine were clamped (i.e., held at a constant level via experimenter-controlled infusions) at, below, or above subjects' self-determined drug satiety thresholds.
resultsUSVs indicated that (1) positive affect was predominantly observed during the drug loading period, but declined quickly to near zero during maintenance and exhibited little relation to calculated drug level, and (2) in contrast, negative affect was observed at sub-satiety cocaine levels, but was relatively absent when body levels of cocaine were clamped at or above subjects' satiety thresholds.
conclusionsThe results reinforce the opponent-process hypothesis of addiction and suggest that an understanding of the mechanisms underlying negative affect might serve to inform behavioral and pharmacological therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.